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    SKKU held the 6th Sungkyun Writing Contest in Vietnam

    SKKU held ‘The 6th Sungkyun Writing Contest’ at Edenstar Saigon Hotel located in Ho Chi Minh, Vietnam on April 25th, where 80 students from 4 countries (Vietnam, Thailand, Laos, and Cambodia) in the region participated. While the students came from different nationalities, they all showed passion and love toward the Korean language. The Korean wave is sweeping accross Vietnam these days. Since 2016, middle and high schools have chosen Korean as a second language course. Professor Tran Van Tu from Van Hien University, who attended the 1st writing contest five years ago as a student, also participated this time with his 6 students. “It feels new to join the event as a professor this time,” said Prof. Tu. The subject of the writing was ‘reconciliation.’ The gold prize went to Tran Nguyen Minh Thu from University of Social Sciences and Humanities at Vietnam National University Ho Chi Minh City. In her writing, she said, “In high school, I saw some friends were getting into arguments over minor things and couldn’t find a solution to get along again. The most important thing for reconciliation is a true heart.” The silver and bronze prizes went to Luong Vu Nguyet Ha from University of Social Sciences and Humanities at Vietnam National University Ho Chi Minh City, and Tran Tung Ngoc from Ha Noi University of Sciences and Humanities, respectively. SKKU will confer scholarships to those students who received the awards. SKKU holds Sungkyun Writing Contests every year in various regions such as China, Middle East, Europe, and Southeast Asia. The Vice President of the Office of International Affairs said, “We had received a lot of interest in the Sungkyun Writing Contest from students in Southeast Asia, so we doubled up the number of participants this year.”

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    2018 International Summer Semester will be held from June 25th

    The summer of 2018 will be the eleventh SKKU International Summer Semester. While the ISS has provided unique courses based on multidisciplinary themes in the past, in 2018, we have added many engineering courses in response to the global trend shifting towards that area of study. Technology is becoming increasingly integrated into many aspects of people’s lives, which has driven the demand for scholars and professionals with a firm grasp of engineering principles. With 60 courses taught by 40 distinguished professors from top universities, such as Georgia Institute of Technology, King's College London, Nanyang Technological University, and SKKU, students will not only be able deepen their knowledge of the subjects, but also develop various perspectives on current global issues. Furthermore, several fun and diverse cultural activities have been prepared for ISS students to meet and interact with each other, like a barbecue party, taekwondo experience, and more. A fantastic summer is waiting for you here at SKKU ISS!

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    Research on Fabrication of Biomimetic Microfibril Structures using 3D Printing

    In the human body, microfibril structures can be found in several types of tissue, such as muscles, nerves, and even tendons. In particular, muscle tissues have uniaxially-aligned microfibrous structures. The team (first author: Won Jin KIM) led by Geun Hyung KIM (Department of Biomechatronics Engineering at Sungkyunkwan University) fabricated a structure composed of bundled poly (e-caprolactone) (PCL) microfibers coated with collagen. To obtain the bundle of uniaxially-aligned (PCL) microfibers, 4D printing methods using a poly (vinyl alcohol) (PVA) fibrillation/leaching process were used. PVA was dissolved in distilled water to fibrillate the PVA. Then, PCL was added to the PVA solution and mixed. After mixing, the PVA/PCL mixture was printed using a 3D printer. The fabricated 3D structure was immersed in water to leach the fibrillated PVA. By using this simple fabricating method, a uniaxially micropatterned/fibrous PCL bundle was achieved. The fabricated structure was supplemented with collagen to increase the biocompatibility of the PCL bundle. The hybrid microfibrillated structure promoted myoblast proliferation and myogenic differentiation. “Due to the 4D printing process, it was able to have high efficiency in the fabrication of 3D scaffolds with highly aligned microfibrous bundles. In addition, a variety of designs and complex microscale-patterned 3D structures were constructed because of a highly versatile 3D printing method,” Prof. KIM said. Published article: W. Kim, M. Kim, G. H. Kim, Adv. Funct. Mater. 2018, 1800405. Article link: https://onlinelibrary.wiley.com/doi/epdf/10.1002/adfm.201800405

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    Fabrication of a Stable New Polymorph Gold Nanowire with Sixfold Rotational Symmetry

    Gold is the first metal used by humans, and it is deeply involved in human life. This was possible because gold was found to be almost pure in nature and easy to process without heating or melting. As one of the most chemically stable metals, gold adopts only one crystal structure. The crystal structure is closely related to the intrinsic properties of materials. When the crystal structure is changed, physical and chemical properties, including electrical and optical properties, are changed. Therefore, it is important to control the polymorphism to achieve reliable material or device properties. The crystal structure of gold is face-centered cubic (fcc) with 3-fold rotational symmetry by nature. For the first time, Prof. SHIN, Ms. LEE, and Dr. BAE (Department of Energy Science at Sungkyunkwan University) have published a stable hexagonal non-close packed structure (ncp-2H) of gold in Advanced Materials (IF 19.791) as a cover story. They report not only excelent stability of ncp-2H gold, but also different physical properties different from those of fcc. Schematic illustration of the experimental procedures for the confined growth of gold nanowires They fabricated the gold nanowires in a confined system of TiO2 nanotubes via the photoelectrochemical reduction of gold ions. During ultraviolet illumination, excited photoelectrons in the conduction band of TiO2 reduced the Au ions to metallic Au. At the early stage of the nucleation process, various polymorphs are able to be formed; however, they are eventually transformed to fcc, the most thermodynamically stable form in nature. They suggest that isolated ncp-2H gold seeds at the nucleation stage survive and grow by a diffusion-limited process under the nanoscale confinement provided by TiO2 nanotubes. They supported the possibility that nanoscale confinement influenced polymorph formation through control experiments. This study is particularly noteworthy that it suggests that different theories from that of classical thermodynamics are required for nanoscale confined systems. Published article: S. Lee, C. Bae, J. Lee, S. Lee, S. H. Oh, J. Kim, G.-S. Park, H. S. Jung and H. Shin, "Fabrication of a Stable New Polymorph Gold Nanowire with Sixfold Rotational Symmetry," Advanced Materials, 30, 1706261 (2018). (Cover Illustration)

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    Direct Imaging of Two Dimensional Electron Gas by Electron Holography

    Atomically controlled interfaces of complex oxides provide new opportunities for materials design and synthesis. They have been the origin of a wide variety of new physical phenomena and properties, arising primarily from the natural quantum confinement of electrons at these interfaces, involving a strong correlation between the electronic and atomic structure. One notable example is the electronic reconstruction of the interface between insulating perovskite oxides that leads to the formation of an interfacial two-dimensional electron gas (2DEG). The 2DEG is known to be formed from the occupied 3d-orbitals of cations within a few nanometers of the interface and often involve an interplay of electronic states with distinct orbital character and symmetry. Different 2DEGs and the related properties are expected by the orbital-selective quantum confinement which is strongly correlated with the crystallographic orientation. Prof. Sang Ho OH of Department of Energy Science demonstrated that 2DEGs at oxide interfaces can be spatially mapped at subnanometer resolution using in-line electron holography and illustrated the power of this method by looking at the 2DEGs formed at (001) and (111) oriented LaAlO3/SrTiO3 interfaces and showing distinctly different spatial extent and charge density profiles across them. Prof. Sang Ho Oh and his Ph.D. student, Dr. Kyung Song now at KIMS, have successfully calibrated all variables affecting the 2DEG distribution, for example, the sample thickness, the mean inner potential and permittivity (ε), and thereby extracted intrinsic properties of 2DEG. Especially, taking account of the nonlinearity of the permittivity of oxide with electric field is essential, as the presence of the 2DEG leads to strong electric fields near the interface where the 2DEG is confined. The field-dependent permittivity has been calculated via analytical approach based on Landau theory and also directly through DFT calculation. These results provide the first direct evidence of the control of 2DEG properties through the interface orbital configuration and reveal the unprecedented capability of in-line holography to probe oxide heterostructures. According to Prof. OH, the electron holography technique developed in the present work will play an important role in development of future oxide-based electronic devices as it is a unique tool bridging various emergent properties arising from quantized electrons at interfaces, such as ferromagnetism, superconductivity and metal-insulator transition, with the function and performance of devices. The work has been conducted through international collaboration with Prof. Chang-Beom EOM, Prof. Christoph KOCH, Prof. Mark RZCHOWSKI and Prof. Evgeny TSYMBAL, Prof. Young-Min KIM and Prof. Si-Young CHOI and published recently in the March issue of Nature Nanotechnology. A companion paper has been published back to back in Nature Materials, demonstrating the formation of two-dimensional hole gas (2DHG) at the p-type LaAlO3/SrTiO3 interface. The work has been supported by National Research Foundation (NRF) of Korea and AFOSR Asian Office of Aerospace Research and Development (AOARD).

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    Prof. Yong Taik LIM Develops Implantation of Synthetic Immune Niche that Prevents Tumor Recurrance

    Cancer vaccines are an attractive option for improving disease-free survival following surgical resection of solid tumors. However, several clinical studies have shown that while cancer vaccines can routinely induce protection in a prophylactic model, the same vaccines often show only limited therapeutic efficacy. The tumor immunosuppressive network, formed by interactions between cancer cells and host immune cells, is a major obstacle to achieving complete tumor eradication. Myeloid-derived suppressor cells (MDSCs) can be considered critical players in tumor-induced immunosuppression in both animal models and cancer patients, which they have a remarkable ability to suppress the activation and proliferation of T cells. Therefore, the depletion of MDSCs would strengthen immunity of tumor-bearing mice. Recently, Prof. Yong Taik LIM’s group of Sungkyunkwan University reported a novel implantable, engineered 3-dimensional porous scaffolds which were designed to generate synergistic action between MDSC-depleting agents and cancer vaccines consisting of whole tumor lysates and nanogel-based adjuvants. The local peritumoral implantation of the synthetic immune niche (termed immuneCare-DISC, iCD) as a post-surgical treatment in an advanced-stage primary 4T1 breast tumor model generated systemic anti-tumor immunity and prevented tumor recurrence at the surgical site as well as the migration of residual tumor cells into the lungs, resulting in 100% survival. These therapeutic outcomes were achieved through the inhibition of immunosuppressive MDSCs in tumors and spleens by releasing gemcitabine and recruitment/activation of dendritic cells, enhanced population of CD4+ and CD8+ T cells, and increased IFN-γ production by cancer vaccines from the iCD. This combined spatiotemporal modulation of tumor-derived immunosuppression and vaccine-induced immune stimulation through the iCD is expected to provide an immune niche for preventing of postoperative tumor recurrence and metastasis. Figure 1. Schematic diagram showing the design of the immuneCare-DISC

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    Prof. Chun Gwon Park (GBME) develops an immunotherapy technology that can prevent cancer recurrence

    The team of Prof. Chun Gwon Park (Department of Biomedical Engineering at (Sungkyunkwan University) and Prof. Michael Goldberg developed (Harvard Medical School and Dana-Farber Cancer Institute) a localized cancer immunotherapy that prevents tumor recurrence and metastasis after surgical removal in mice. Their findings show that applying cancer immunotherapy in conjunction with surgery could help prevent tumor metastasis, which accounts for 90% of cancer-related deaths. Surgery is the most common treatment for cancer but the resulting healing process places stress on the body and suppresses the immune system, leading to an increased likelihood of metastasis and tumor recurrence. Previous researches have explored the possibility of using cancer immunotherapy to counter the drawbacks of surgery, but response rates are often poor and need improvement. To address the shortcomings of both methods, Prof. Park and his colleagues created biodegradable gel discs that slowly release different types of innate immune system agonists, or molecules that trigger a response from the innate immune system. The team then implanted the discs into the surgical sites of mice with breast cancer, lung cancer or melanoma after removing their tumors and monitored the mice over the next 12 weeks. They found that mice which were implanted with gels containing agonists did not develop tumor recurrence or secondary tumors in other regions of their body, and had higher survival rates than mice that did not receive the gel discs. More importantly, the study also showed that delivering the compounds via the gel was safe and more effective in preventing tumor recurrence than intravenous administration or local injections. “This approach has the potential to deliver immunotherapy in a manner that focuses the therapy at the site of interest within a critical time window. We are extremely encouraged by the results of this study and are hopeful that this technology will be adapted for patients and testing in clinical trials in the near future,” Prof. Park and Prof. Goldberg say. Published article: C. G. Park, C. A. Hartl, D. Schmid, E. M. Carmona, H.-J. Kim, M. S. Goldberg, Extended release of perioperative immunotherapy prevents tumor recurrence and eliminates metastases. Sci. Transl. Med. 10, eaar1916 (2018). Article link: http://stm.sciencemag.org/content/10/433/eaar1916

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    Special Lectures to be given by Prof. Atsushi OMURA from the University of Tokyo

    Sponsored by the Research & Business Foundation and CAMPUS Asia project unit, SKKU-IEALP of the SKKU Law School (Dean: Man Kee MIN) invited Prof. Atsushi OMURA from University of Tokyo as a visiting professor to SKKU to provide special lectures with the theme of “Comparative Civil Law between Korea and Japan.” The lecture was originally prepared as a part of Japanese law, one of the fields at the SKKU Law School. However, other students who are seeking master’s or doctoral degrees, students in the department of Global Leader, and CAMPUS Asia Project participants are also welcome to attend. For students with a basic level of Japanese, interpretation will be provided. The lectures will take place in lecture room 207 of the Law School Building. The schedule is as follows: - 1st lecture (1:00PM, Monday, March 26th): Civil society - 2nd lecture (7:00PM, Tuesday, March 27th): Aging society and social disparities - 3rd lecture (7:00PM, Wednesday, March 28th): Recession of living profit and acceleration of cession of an obligation - 4th lecture (7:00PM, Thursday, March 29th): Article 10 of Customer Contract Law and the principles of precedents - 5th lecture (7:00PM, Friday, March 30th): Constitutional law, social security act, and law of property - 6th lecture (10:00AM, Saturday, March 31st): Liberalization of group foundation and liberty and equality of members

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    University College held ‘Peer Leader Workshop 2018’

    The SKJU University College (Dean: Hong Joon YOO) held their ‘Peer Leader Workshop 2018’ on March 15th (Fri) at the 600th Anniversary Hall in the Humanities and Social Sciences campus. At the event, a total of 110 people participated, including 4 ‘Peer Leaders (PL)’ of the Learning Community (LC), freshmen entering in 2018, and Sungkyun mentors from both the Seoul and Suwon Campuses. It began with an introduction of the event from a Sungkyun mentor and a welcome address from the dean, followed by a PL appointment certificate conferment ceremony, experience sharing, team projects by PL groups, and mentoring between Sungkyun mentors and PL students.. Eun Hye KIM, a representative of PL, said, “It is a great honor for me to receive this PL appointment certificate as a representative of PL. I will work hard to become like senior students who came to share their experience and stories. Lastly, thank you all Sungkyun mentors and people who prepared this event.” The Peer Leader Workshop by the University College aims to develop the leadership of freshmen, to strengthen companionship, and to broaden exchange opportunities between the Seoul and Suwon campuses.

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    Traditional and Unique Freshman Orientation, ‘Shin Bang Rye’ was held

    To welcome the new semester of 2018, 250 freshmen, including international students, participated in SKKU’s traditional and unique orientation ‘Shin Bang Rye’, held at the Humanities and Social Sciences Campus from March 10th ~ 11th. ‘Shin Bang Rye’ is a traditional freshmen orientation stemming from the Joseon Dynasty, where newcomers can learn about the education curriculum, campus life, and expected behavior. The event that commenced during the ‘Shin Bang Rye’ ritual process are as follows: Al-Sung (commemorative rites in front of Dae-Sung-Jun), Sang-Eup-Rye (formal greetings between seniors and freshman students), Shin-Bang-Rye (welcoming party by sharing food), and Myun-Shin-Rye (initiation ceremony where senior students provides various tasks to freshmen). For 2018 Shin Bang Rye, 27 international students from various countries, including China, France, Morocco, Germany, Czech Republic, Vietnam, etc. participated to experience the culture and history of the Joseon Dynasty. “We tried to make a unique orientation by combining traditional and modern environments. We will continuously try our best to organize special and unique events with novel ideas,” said student Min Gyung OH, president of the student association ‘Chung Ryang’.

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