성균관대학교

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  • A Study on the Changes of Students' Social Emotional Experience and Learning Patterns then and now COVID-19 pandemic

    Education Prof. BAE, SANG HOON

    A Study on the Changes of Students' Social Emotional Experience and Learning Patterns then and now COVID-19 pandemic

    The Education and Future Research Institute (Director Bae Sang-hoon*) published its findings on the changes in students' social emotional experiences and learning patterns around COVID-19. This study was conducted as part of a global joint study conducted with Harvard University's Partnership in Education and Resilience (PEAR) Institute and the Free University of Berlin, which is world-renowned in children's social and emotional development and after-school activities. ※ Prof. Bae (Department of Education) serves as the Editor in chief of world-renowned journal, International Journal for Research on Extended Education in the field of extra-curricular activities. This study is a pilot study of global joint research led by the World Education Research Association International Research Network and participated by 15 countries. The research team (Jin Hye-won in master course, undergraduate researchers Jeon Ji-hye, Jeon Min-kyung, Kim li-yeon, and Jo Su-hyun) analyzed how the student's social emotional experience and learning patterns changed between "the second semester of 2019" and "the first semester of 2020 when School was shut." This study used a questionnaire jointly produced by Sungkyunkwan University and Harvard University researchers, and analyzed the response data of 261 elementary school students, 218 middle school students, and 396 high school students. < Study Contents > Area Factor Source Experience of social emotional development Action Oriented PEAR Perseverance PEAR Relationships with Adults PEAR Optimism PEAR Distress - Learning ability Perception on schools - Self-Directed learning Education and Future Research Institute Collaborative learning Education and Future Research Institute < Harvard Child Development Model> ※ Malti, T., Zuffiano, A., & Noam, G. (2017). Knowing every child: Validation of the holistic student assessment (HSA) as a measure of social-emotional development, Society for Prevention Research. DOI 10.1007/s11121-017-0794-0 The research team pointed out that all social and emotional development factors fell then and now COVID-19. In particular, it was noted that "action oriented” and "Optimism" have decreased significantly. According to Harvard's child development model, students have experienced active participation in social life by doing various physical activities in the early stages of development, and these participation experiences serve as the foundation for the next stage of social emotional development. For this reason, many developed countries emphasize after-school activities in early childhood. The research team pointed out that “action-oriented” decreased the most in the elementary school group, which was interpreted as a result of the decrease in individual external activities amid limited movements for school, school sports, and after-school activities. Researchers at the Institute for Education and Future predicted that social distancing under COVID-19 will continue for a while, stressing the need for students to follow quarantine rules while properly doing physical activities such as walking in park with family and friends. He also pointed out that fewer activities and social interactions with peers could seriously affect students' social emotional development, and that parents' special attention and careful guidance are needed to comply with quarantine rules such as wearing masks in well-ventilated spaces. “Optimism”is a necessary developmental experience, especially at a mature stage on development. According to the research team, this perception has decreased significantly since COVID-19. The research team said that the social situation, in which expectations for the end of COVID-19 are reduced due to repeated large-scale spread of COVID-19, is believed to have had a negative impact on forming a positive attitude toward life. In addition, the researchers found that the decrease in activities (meeting friends, exercises to relieve stress, etc.) that could gain positive emotions in social communities as students spent more time indoors had a negative impact on forming positive perceptions of life. The researchers emphasized that positive perception of life is a key factor in enhancing learning participation and academic performance by promoting academic motivation and social exchange. Therefore, special interest and measures are needed for students who are experiencing alienation and depression in isolation. Professor Bae Sang-hoon, who led the research team, said, "It should be highly appreciated that Korea has maintained the safety and health of the people through K-Discipline. However, it is time to pay attention to the developmental delays and educational deficits of students in the face of the situation where the school's restrictions on schooling and the expansion of non-face-to-face online classes become new normal. "“In particular, if students miss out on the social and emotional experiences they should have at each developmental stage, this may be a difficult developmental loss to recover easily, so special attention is needed in schools and families,” he said. “If we were concerned about technical support for stable online classes as we had to do online classes in 2020, we should now make more efforts to improve the quality of education.” he said. In particular, the education authorities and schools should make a lot of efforts to create class design and evaluation plans to promote vulnerable self-directed learning and cooperative learning in online classes. The development and learning of students is based on continuous and systematic interaction. If social distance and remote learning are expanded, such intellectual interaction, emotional exchange, and social activities may be reduced. In future society, empathy and consideration are essential competencies to live as mature members of society. Therefore, class design is required to supplement them and parents' attention is required during the time of staying at home. Finally, Professor Bae noted that the delays and learning deficits of socio-emotional development that appeared before and after Corona 19 were more significant in socio-economic vulnerable groups, and it is an important social and educational task to build an educational safety net for these classes and to take careful care.

  • Development of a 3D Liquid Transporting Diode Surface Using Nature-inspired Technology

    Mechanical Engineering Prof. LEE, JIN KEE ·Dr. MinKi Lee

    Development of a 3D Liquid Transporting Diode Surface Using Nature-inspired Technology

    Sungkyunkwan University (President Dong Ryeol Shin) announces that Prof. Jinkee Lee in School of Mechanical Engineering & Institute of Quantum Biophysics has developed a 3D liquid transporting diode surface using nature-inspired technology (first author Dr. MinKi Lee). This liquid transporting system has advantages for easy fabrication, cost-effectiveness, high scalability and shows the world's highest performance with novel 3D structure. When a liquid droplet is dispensed on the surface, the liquid transports uni-directionally by the passive capillary control from the structures of the liquid diode. Up to now, diode surfaces have been manufactured using lithography processes or 3D printer, which have drawbacks of limited size with complicated manufacturing processes, and also they show low liquid transport performance. Many researchers have been investigating the diode surface but it is quite challenging to increase both the transport performance and the ease of surface manufacturing, simultaneously. Prof. Jinkee Lee developed nature-inspired diode surface, which mimics the surface from nature such as horned lizard and pitcher plant. The 3D diode surface has a wedge structure consisting of repeating saw-like V-grooves. This surface utilizes the capillary force generated by the 3D topographical shape that pins liquid at one size and makes it flow to the other side. The fabrication of 3D diode surface is easy, fast, cost-effective and scalable because it is processed simply using a laser cutter. Professor Jinkee Lee said, “This 3D water transport diode surface can be applied as an original technology applying to microfluidic diagnostic chips, material synthesis, heat transfer enhancement and even fog collection because of its superior performance and easy fabrication.” This study was supported by the National Research Foundation of Korea (NRF; 2020R1A2C3010568) and the Korea Environment Industry & Technology Institute (KEITI; 2019002790003), and was published online on March 20, 2021 in Advanced Functional Materials (IF=16.836). ※ Title of paper : “Enhanced Liquid Transport on a Highly Scalable, Cost‐Effective, and Flexible 3D Topological Liquid Capillary Diode”

  • Development of New Treatment for PDT for Hypoxic Cancer,  Suggestion of New Theranostic Method  for PDT

    Chemistry Prof. LEE, JINYONG

    Development of New Treatment for PDT for Hypoxic Cancer, Suggestion of New Theranostic Method for PDT

    [Development of a New Treatment for Photodynamic Theraphy (PDT) for Hypoxic Cancer] A research collaboration team led by Prof. Jin Yong Lee (co-first author: Hao Li, Dept. of Chemistry) and Prof. Jong Seung Kim at Korea University (co-first authors: Dr. Miae Won and Dr. Seyoung Koo) announced that they have developed a new treatment for photodynamic therapy for hypoxic cancer through joint research. Since photodynamic therapy requires reactive oxygen, it has limitations in its application to hypoxic cancer. The research team proposed a new method for photodynamic therapy for hypoxic cancer by simultaneously causing reactive oxygen generation and inhibition of GST-pi. The joint research team of Sungkyunkwan University and Korea University combines BPS, an existing photosensitizer, with EA to generate reactive oxygen and inhibits GST-pi, an enzyme that interferes with photodynamic therapy by free radicals, to improve the efficiency of photodynamic therapy for hypoxic cancer. Currently, photodynamic therapy is clinically approved, but reactive oxygen must be present for the treatment. Therefore, there is a limit to application to hypoxic cancer that lacks oxygen around cancer cells. In order to overcome this, various attempts have been made to transport oxygen and to generate oxygen, but there were difficulties due to side reactions from excessive production of active oxygen. To solve these difficulties, the joint research team improved the performance of photodynamic chemotherapy for hypoxic cancer by covalently binding EA to BPS, an existing photosensitizer. EA-BPS serves to scavenge glutathione (GSH) by delivering EA and reduce the activity of the GST-pi enzyme. In particular, through experiments, it was confirmed that EA-BPS lowered the activity of GST-pi by promoting lysosome decomposition and lipid peroxidation. In addition, docking and molecular dynamics (MD) simulations were performed to reveal that five residues (chain A: F7, W37 and Y107; chain B: Y107 and A120) play an important role in the active site, and it was revealed that EA-BPS was interacting with GST-pi enzyme pocket through two subunits instead of one subunit. Professors Lee and Kim said, "The EA-BPS developed in this study has proven its excellent therapeutic effect in a xenograft tumor mouse model, and based on this, we are looking for ways that can be applied to the clinic. It is expected to present a new path for the development of photodynamic therapy for hypoxic cancer." The results of this study was published in the journal "Angewandte Chemie International Edition (ACIE; IF=12.959)" (Feb 8, 2021). [ Suggestion of a New Method that Could be Used in an Easy and Convertable Theranostic for Photodynamic Theraphy] A research collaboration team led by Prof. Jin Yong Lee (co-first author: Hao Li, Dept. of Chemistry) and Prof. Juyoung Yoon at Ewha Womans University (co-first authors: Dr. Hong-Bo Cheng and Dr. Bin Qiao) announced that they have developed a new reversible photodynamic chemotherapy method through joint research. It is very difficult and challenging to develop photosensitizers that can reversibly control free radicals for photodynamic therapy. The research team used porphyrin and DIA as building blocks to create HSA-DIA-porphyrin nanoparticles through self-assembly with HSA, which suggested a new method that could be used in an easy and convertible theranostic for photodynamic immunotherapy. The development of activatable photosensitizers to allow for the reversible control of singlet oxygen (1O2) production for photodynamic therapy (PDT) faces great challenges. Fortunately, the flourishing field of supramolecular biotechnology provides more effective strategies for activatable PDT systems. The joint research tream developed a new reversible PDT on a switch that controls the 1O2 generation of self-assembled albumin nanotheranostics in vitro and in vivo. A new molecular design principle of aggregation-induced self-quenching photochromism and albumin on-photoswitching was demonstrated using a new asymmetric, synthetic diarylethene moiety DIA. The photosensitizer porphyrin and DIA were incorporated as building blocks in a glutaraldehyde-induced covalent albumin cross-linking nanoplatform, HSA−DIA−porphyrin nanoparticles (NPs). More importantly, the excellent photoswitching property of DIA enables the resultant nanoplatform to act as a facile, switchable strategy for photodynamic-immunotherapy. In addition, through docking and molecular dynamics (MD) simulations, three binding modes (heme binding site, cracked binding site, and other binding sites bound to the FA7 region) were identified, and HSA (Human Serum Albumin) preferred antiparallel fashion in binding to DIA rather than parallel. Prof. Lee and Prof. Yoon said, "The synthesis of a non-invasive trigger that reversibly regulates the production of free radicals is a very important in the development of photodynamic chemotherapy drugs, and this study presents a new avenue." The results of this study was published in "Journal of the American Chemical Society (JACS; IF=14.612)". (Feb 10, 2021)

  • Development of a New Technology for 2D Transition Metal Chalcogenides

    Mechanical Engineering Prof. KIM, TAESUNG ·Prof. Ji Won Suk, Ph.D. Hyeong-U Kim

    Development of a New Technology for 2D Transition Metal Chalcogenides

    Prof. Kim, Taesung (School of mechanical engineering/SAINT) developed a new technology for two-dimensional (2D) transition metal chalcogenides (TMDs) for the first time in 2015 using plasma-enhanced chemical vapor deposition (PE-CVD) instead of SiOx and SiNx. It is great significance in overcoming the limitations of conventional synthetic techniques (thermal chemical vapor deposition, mechanical exfoliation) such as high process temperature (>550 oC) and small dimensions (size a few cm). ICP type with shower type of nozzle can achieve high uniformity with 4-inch large size using PECVD. In addition, the high-density plasma of ICP has unique properties by inducing the nano size of grain. From 2015 to the present, various 2D TMDs have been successfully synthesized using PE-CVD and many papers(※) and patents have been published. Also, this time, we succeeded in fabricating TMDs-TMDs heterostructure for 4-inch wafer scale. Prof. Taesung Kim’s group (Hyunho Seok, Chaitanya Kanade) and Dr. Hyeong-U Kim (KIMM) developed a new technology using the heterostructure of TMDs-TMDs with experience in synthesis know-how using PECVD. Moreover, Prof. Ji Won Seok’s group (Yonas T. Megra) analyzed the interfacial adhesion properties between the synthesized MoS2-WS2 heterostructures and substrates. It validates the structural stability of the interfaces between MoS2 and WS2. Regarding this research, Prof. Kim said, “We can use cold plasma to overcome the limitations of conventional heterostructure fabrication such as, low uniformity and small size and can be applied to TMDs heterostructure research with high potential for mass production in the near future.” A related research paper, ‘Low-Temperature Synthesis of Wafer-Scale MoS2-WS2 Vertical Heterostructures by Single-Step Penetrative Plasma Sulfurization’ was published in ‘ACS Nano’ (I.F.=14.588, JCR <10%). This research was supported by the National Research Foundation of Korea (NRF) 2018R1D1A1B07040292, 2017R1A2B3011222, and 2019R1A2C2089785. ※ PECVD 2D Materials Synthesis Related Papers (Prof. Kim, Taesung’s Group) 1) Low-Temperature Synthesis of Large-Scale Molybdenum Disulfide Thin Films Directly on a Plastic Substrate Using Plasma-Enhanced Chemical Vapor Deposition (H.-U. Kim et al., Advanced Materials, 27, 2015, 5223-5229) 2) Highly uniform wafer-scale synthesis of α-MoO3 by plasma enhanced chemical vapor deposition (H.-U. Kim et al., Nanotechnology, 28, 2017, 175601) 3) Low-temperature wafer-scale growth of MoS2-graphene heterostructures (H.-U. Kim et al., Applied Surface Science, 470, 2019, 129-134) 4) Wafer-Scale and Low-Temperature Growth of 1T-WS2 Film for Efficient and Stable Hydrogen Evolution Reaction (H.-U. Kim et al., Small, 16, 2020, 1905000) 5) Flexible MoS2–Polyimide Electrode for Electrochemical Biosensors and Their Applications for the Highly Sensitive Quantification of Endocrine Hormones: PTH, T3, and T4 (H.-U. Kim et al., Analytical Chemistry, 92, 2020, 6327-6333) 6) Realization of Wafer‐Scale 1T‐MoS2 Film for Efficient Hydrogen Evolution Reaction (H.-U. Kim et al., ChemSusChem, 2021) doi.org/10.1002/cssc.202002578 7) Low-Temperature and Large-Scale Production of Transition Metal Sulfide Vertical Heterostructure and Its Application for Photodetectors (Chaitanya et al., ACS Applied Materials & Interface, 2021) 8) Low-Temperature Synthesis of Wafer-Scale MoS2-WS2 Vertical Heterostructures by Single-Step Penetrative Plasma Sulfurization (H. Seok et al., ACS Nano, 15, 2021, 707-718)

  • Chloroplast Evolution Revealed by Research on Photosynthetic Amoeba

    Biological Sciences Prof. YOON, HWAN SU

    Chloroplast Evolution Revealed by Research on Photosynthetic Amoeba

    A research team led by Prof. Hwan Su Yoon (Department of Biological Sciences at Sungkyunkwan University), together with the research team of Prof. Bhattacharya published a paper on the evolutionary process of chloroplasts in the photosynthetic amoebae, Paulinella micropora. Chloroplasts are the powerhouses of many aquatic and terrestrial ecosystems. The chloroplast in algae and plants originated more than 1 billion years ago and therefore offers limited insights into the initial stages of chloroplast evolution. To address this issue, we focused on the photosynthetic amoeba Paulinella micropora that acquired chloroplast recently (∼124 million years ago) from the independent cyanobacterial origin. Paulinella genome revealed how foreign genes from cyanobacteria and other bacteria affected during the evolution of the chloroplast. In plant cells, proteins involved in photosynthesis are targeted to the chloroplast. Short amino acid sequences called signal peptides are involved in this process. The research team discovered a unique chloroplast signal peptide in Paulinella, which has a plant-independent origin. Moreover, most of the chloroplast targeted proteins were originated from amoeba host, suggesting dominant host contribution to chloroplast evolution. As a model organism showing what happened in the early evolution process of plants, the research on photosynthetic Paulinella is important. Paulinella genome information can be used as basic data for research on applied fields such as synthetic biology and genetic engineering that maximize photosynthesis efficiency. [Image] photosynthetic Paulinella Published article: Duckhyun Lhee, JunMo Lee, Khaoula Ettahi, Chung Hyun Cho, Ji-San Ha, Ya-Fan Chan, Udi Zelzion, Timothy G Stephens, Dana C Price, Arwa Gabr, Eva C M Nowack, Debashish Bhattacharya, Hwan Su Yoon, Amoeba Genome Reveals Dominant Host Contribution to Plastid Endosymbiosis, Molecular Biology and Evolution, Volume 38, Issue 2, February 2021, Pages 344–357, https://doi.org/10.1093/molbev/msaa206

  • Suggests Possibility of Applicable Personalized Cancer Therapy Using Radiation Therapy

    Integrative Biotechnology Prof. JEON, YOUNG-JUN

    Suggests Possibility of Applicable Personalized Cancer Therapy Using Radiation Therapy

    - The current study shows that the mutations in KEAP1/NFE2L2 genes have a power to predict for local recurrence of the patients after radiation therapy. - The resistance evoked by these mutations may allow personalized radiosensitization of KEAP1/NFE2L2-driven NSCLC, suggesting that the concept of the cancer personalization could be extended to radiation therapeutics. Figure 1. Schematic diagram showing the study design about which the KEAP1/NFE2L2 mutations are predictive biomarkers of local recurrence after radiation treatment in NSCLC Image Excepted : Cancer Discovery DOI:10.1158/2159-8290.CD-20-0282 Young-Jun Jeon’s research teams in the department of Integrative Biotechnology, Sungkyunkwan university published that the mutations in KEAP1/NFE2L2 gene could predict local recurrence of the NSCLC patients after radiation therapy. This study was done by collaboration with Stanford University and supported by NRF grant (NRF-2020R1F1A1071579). Personalized cancer therapy has not been routinely applied to the cancer patients using radiation therapy. To this end, the teams analyzed 232 consecutive patients with localized NSCLC using next generation sequencing (NGS) analysis and found that an important anti-oxidant responsible factor, KEAP1/NFE2L2 genes harboring oncogenic mutations were highly correlated with the local recurrence of NSCLC patients after radiation therapy but not surgery. Subsequently they generated CRISPR-knocked out lung cancer cell lines for KEAP1 genes to test whether a patient derived-KEAP1 or NFE2L2 mutation has oncogenic property and found the pathogenic mutations of the critical anti-oxidant responsible genes are associated with radiation resistance. Also, subsequent cell biological approaches revealed that the inhibition of glutamine metabolic pathway known as an addicted pathway in lung cancer may allow personalized re-sensitizing KEAP1/NFE2L2-driven NSCLC. Figure 2. Strategy for assessing KEAP1/NFE2L2 mutation functional classification using isogenic lung cancer cell lines This study not only claimed the cancer personalization applicable to treatment strategy with radiation therapy in other localized cancers but also suggest a new paradigm in the personalized cancer therapeutics. These results featured on the cover in Cancer Discovery (Vol 10, Issue 12), a top ranked journal in the fields of Oncology (Impact factor – 29.497). Young-Jun Jeon’s research team is currently developing a NGS library platform to analyze circulating tumor nucleic acids from patient blood plasma as a liquid biopsy tool, which will be eventually applied to identify novel mechanistic and prognostic biomarkers by combining cancer biological approaches.

  • Development of highly efficient and long-lasting electrocatalyst for water oxidation

    Chemistry Prof. LEE, HYOYOUNG

    Development of highly efficient and long-lasting electrocatalyst for water oxidation

    Abundant. Clean. Flexible. Alluring enough to explain why hydrogen, the most common molecule in the universe happens to have its name as part of an national Hydrogen and Fuel Cell Day. Chosen to signify hydrogen's atomic weight of 1.008, the U.S. Department of Energy's Office of Energy Efficiency and Renewable Energy celebrates advances in hydrogen-use technology every October 8 since 2015. When hydrogen is consumed in a fuel cell (which takes the water molecule H2O and seperates it into oxygen and hydrogen, a process called electrolysis), it only produces water, electricity, and heat. As a zero-carbon energy source, the range of its potential use is limitless: transportation, commercial, industrial, residential, and portable. While traditional hydrogen production processes required fossil fuels or CO2, electrolysis produces “green hydrogen” from water molecules. Since water cannot be split into hydrogen and oxygen by itself, the electrochemical hydrogen-water conversion needs highly active electrocatalysts. The conventional water electrolysis, however, faces technological challenges to improve the efficiency of the water-splitting reaction for the sluggish oxygen evolution reaction. Noble metal-based ruthenium oxide (RuO2) and iridium oxide (IrO2) are used to enhance the oxygen generation rate. However, these noble metal catalysts are very expensive and show poor stability under long-term operation. Led by Associate Director LEE Hyoyoung of the Center for Integrated Nanostructure Physics within the Institute for Basic Science (IBS) located at Sungkyunkwan University, the IBS research team developed a highly efficient and long-lasting electrocatalyst for water oxidation using cobalt, iron, and a minimal amount of ruthenium. “We used ‘amphiphilic block copolymers’ to control electrostatic attraction in our single ruthenium (Ru) atom-bimetallic alloy. The copolymers facilitate the synthesis of spherical clusters of hydrocarbon molecules whose soluble and insoluble segments form the core and shell. In this study, their tendency for a unique chemical structure allows the synthesis of the “high-performance” single atomic Ru alloy present atop the stable cobalt iron (Co-Fe) metallic composite surrounded by porous, defective and graphitic carbon shell,” says LEE Jinsun and Kumar Ashwani, the co-first authors of the study. “We were very excited to discover that pre-adsorbed surface oxygen on the Co-Fe alloy surface, absorbed during the synthesis process, stabilizes one of the important intermediates (OOH*) during the oxygen generation reaction, boosting the overall efficiency of the catalytic reaction. The pre-absorbed surface oxygen has been of little interest until our finding,” notes Associate Director Lee, the corresponding author of the study. The researchers found that four hour-annealing at 750°C in an argon atmosphere is the best appropriate condition for the oxygen generating process. In addition to the reaction-friendly environment on the host metal surface, the single Ru atom, where oxygen generation takes place, also fulfills its role by lowering the energy barrier, synergistically enhancing the efficiency of oxygen evolution. The research team evaluated the catalytic efficiency with the overvoltage metrics needed for the oxygen evolution reaction. The advanced noble electrocatalyst required only 180 mV (millivolt) overvoltage to attain a current density of 10 mA (milliampere) per cm2 of catalyst, while ruthenium oxide needed 298 mV. In addition, the single Ru atom-bimetallic alloy showed long-term stability for 100 hours without any change of structure. Furthermore, the cobalt and iron alloy with graphitic carbon also compensated electrical conductivity and enhanced the oxygen evolution rate. Associate Director Lee explains, “This study takes us a step closer to a carbon-free, and green hydrogen economy. This highly efficient and inexpensive oxygen generation electro-catalyst will help us overcome long-term challenges of the fossil fuel refining process: to produce high-purity hydrogen for commercial applications at a low price and in an eco-friendly manner.” The study was published online on November 4 in the journal Energy & Environmental Science. [Image 1] Crystal structure of surface oxygen-rich metal alloy (top left). Oxygen and hydrogen are generated during a water electrolysis reaction (top right). The designed catalyst exhibits the best oxygen evolution activity with minimal overpotential (bottom panels). - References Jinsun Lee, Ashwani Kumar, Taehun Yang, Xinghui Liu, Amol R. Jadhav, G. Hwan Park, Yosep Hwang, Jianmin Yu, Chau T. K. Nguyen, Yang Liu, Sara Ajmal, Min Gyu Kim and Hyoyoung Lee. Stabilizing OOH* intermediate via pre-adsorbed surface oxygen of single Ru atom-bimetallic alloy for ultralow overpotential oxygen generation. Energy & Environmental Science. 2020. DOI: 10.1039/D0EE03183F

  • Suggests the Possibility of Diagnosing Chronic Pain through Neuroimaging

    Biomedical Engineering Prof. WOO, CHOONG-WAN

    Suggests the Possibility of Diagnosing Chronic Pain through Neuroimaging

    Pain is subjective, by definition. No onecan truly experience the others’ pain. Though the need for objective markers ofpain is pressing to help develop more effective diagnosis and treatments, the currentstate-of-the-art pain evaluation method is still self-report by asking patients“how much pain do you feel now?” Pain can be initiated by externalnociceptive input, but multiple factors can influence and modify painexperience, such as emotions, thoughts, beliefs and past memories, andtherefore complex interactions among multiple brain system (a.k.a., functionalconnectome*) are known to be important for pain. Chronic pain, which ruinseveryday life and causes tremendous socio-economic costs, is also known to be adisease of functional brain connectome. However, there has been no objectiveassessment of pain based on the functional brain connectome. * Functional brain connectome: A map ofsystems-level functional interactions across multiple brain regions A new study conducted by a research team ofSungkyunkwan University led by Choong-Wan Woo (Assistant professor, Departmentof Biomedical Engineering) developed a new neuroimaging biomarker of sustainedpain based on functional brain connectome in collaboration with Tor Wager(Professor, Department of Psychological and Brain Sciences) at Dartmouth College.The research team invented an effective and safe way to induce pain for a while(longer than 10 minutes) by applying capsaicin on participants’ tongue. Theyrecorded patterns of brain functional connectivity while participants wereexperiencing sustained pain using functional Magnetic Resonance Imaging (fMRI).The functional connectome-based biomarker not only succeeded to predictsubjective ratings of pain intensity across 109 participants, but it also predictedoverall severity of pain symptoms across 192 patients with clinical back pain. “This study showed brain responses to experimentallyinduced sustained pain are quite similar to the brain activity patterns during clinicalpain”, said Professor Choong-Wan Woo, who is the corresponding author of thiswork. He added, “We believe this study provide new insight into understandingneural mechanisms of clinical pain, and ultimately can help many patientssuffering from chronic pain”, “Our results suggest that not only a set oflocal brain regions known to be related with pain but also the dynamic,functional interactions of whole brain are important for understanding theneural mechanisms of sustained pain” said Jae-Joong Lee, the first author ofthe study and a Ph.D. candidate in the Department of Biomedical Engineering,Sungkyunkwan University. He also added “This is a new evidence that pain is amulti-dimensional experience mediated by functional brain connectome.” This study was supported by Institute forBasic Science (IBS-R015-D1), National Research Foundation of Korea (2019R1C1C1004512),Ministry of Science and ICT, Korea (2019-0-01367-BabyMind), and Korean BrainResearch Institute (18-BR-03). The paper has published in Nature Medicine(Impact Factor 36.130) on Jan 4, Monday. ※ You can find its video abstract via thefollowing YouTube link: https://youtu.be/U_Y7vwGw5So [Figure 1] A functional connectome biomarkerpredictive of sustained pain intensity, named the Tonic Pain Signature (ToPS).Each line represents predictive weights of functional interactions between twodistinct brain regions in the biomarker model. [Figure 2] Selected connections of the functionalconnectome biomarker that are most import in prediction of sustained painintensity.

  • Revealing a Clue to the Solution of the Final Piece of the Puzzle Towards Commercialization of Perovskite Optoelectronic

    SKKU Advanced Institute of Nano Technology Prof. LEE, JIN WOOK

    Revealing a Clue to the Solution of the Final Piece of the Puzzle Towards Commercialization of Perovskite Optoelectronic

    Prof. Jin-Wook Lee's research team at SKKU Advanced Nano Technology (SAINT) and Department of Nano Engineering has published significant research results to uncover the final piece of the puzzle for the commercialization of perovskite optoelectronic devices. The four research papers associated with it were published in Nature Communications, Advanced Functional Materials, Journal of the American Chemical Society, and Joule (impact index=29.155), the top 2% journal in the material research field. Optoelectronic devices based on metal halide perovskite materials exhibit performance comparable to those of the commercialized devices, undertaken to be commercialized by domestic and overseas research institutes and companies. In particular, perovskite solar cells are in the limelight as a next-generation solar cell due to power conversion efficiency exceeding 25%, approaching that of previously commercialized silicon solar cells, and are expected to be much economical in manufacturing cost aspect. The final puzzle for the commercialization of perovskite devices regarding the current issue is the suppression and passivation of crystal defects to improve device lifetime. Low-temperature solution-processed perovskite thin films inevitably possess a high density of ionic defects. These ionic defects are easily migrated under built-in or applied electric field during device operation, degrading the charge transport ability, which ultimately fatal to the device lifetime. Prof. Jin-wook Lee's research team developed core technologies to dramatically reduce the defect concentration in the perovskite thin-film by applying a solid-phase epitaxial crystal growth method (Nat. Commun., 2020, 11, 5514) and developed a method to effectively passivate defects in the grown thin film without side effects. (Joule, 2020, 4, 2426; Adv. Funct. Mater., 2020, 2007520; J. Am. Chem.Soc. 2020, 142, 20071). The solar cell and LED devices based on thetechnologies showed superior performance and lifetime compared to control devices. These technologies developed by Professor Jin-wook Lee's research team not only suggested important scientific clues to resolve the instability issue of perovskite photoelectric devices but are also expected to become source proprietary technologies for the commercialization of perovskite optoelectronic devices in the future. ※Related publications 1)Shallow iodine defects accelerate the degradation of α-phase formamidinium perovskite, Joule, 2020, 4, 2426. (Corresponding author- Prof.Jin-Wook Lee) 2)Solid-phase hetero epitaxial growth of α-phase formamidinium perovskite, Nature Communications, 2020, 11, 5514. (First author and corresponding author-Prof. Jin-Wook Lee) 3)Stable and efficient methylammonium, cesium, and bromide-free perovskite solarcells by in-situ interlayer formation, Advanced Functional Materials,2020, 2007520. (Corresponding author- Prof. Jin-Wook Lee) 4)Molecular interaction regulates performance and longevity of defect passivation for metal halide perovskite solar cells, Journal of the American ChemicalSociety, 2020, 142, 20071. (Corresponding author- Prof. Jin-Wook Lee) Schematic illustration: growth of perovskite thin film by solid-phase epitaxiay (a) Schematic diagram of a solid-phase epitaxy method using a controlled phase conversion. (b) Comparison of phase conversion kinetics between conventional thin film growth and epitaxial growth methods. (c, d) X-ray diffraction patterns (XRD) and photoluminescence (PL) lifetime of the films grown by a conventional method and nano-heteroepitaxial (NHE) growth method.

  • Development of the World's First Fluorescence Amplifier Sensor for Detection of Nitroaromatic Compounds

    Pharmacy Prof. KIM, IN SU

    Development of the World's First Fluorescence Amplifier Sensor for Detection of Nitroaromatic Compounds

    A research team led by Professor In Su Kim from the School of Pharmacy, Sungkyunkwan University (President: Dong Ryeol Shin); Professor Jung Su Park from the School of Chemistry, Sookmyung Women’s University and Professor Jonathan L. Sessler from the School of Chemistry, University of Texas, Austin, U.S. developed the world's first ratiometric fluorescence amplification sensor that can selectively detect nitro-explosive compounds. The findings were selected as a cover page in the October issue of the online edition of Journal of the American Chemical Society (IF = 14.612), a world-renowned journal in the field of chemistry. Nitroaromatic compounds are known to be explosive substances that react vigorously, releasing toxic gases in the atmosphere. Typical explosive substances as trinitrotoluene (TNT) and nitromethane are currently being used as basic raw materials for the manufacture of explosives, including gunpowder. Nitroaromatic compounds are also part of pharmaceutical manufacturing processes of several APIs such as nifedipine, sildenafil (Viagra) etc. Such class of compounds require special attention while handling as they may cause explosion as a result of heat or impact. In this study, Professor In Su Kim's research team and collaborators developed the world's first fluorescence amplifier sensor that can selectively adopt various nitroaromatic compounds by fluorescence indicator displacement assay method depending on binding affinities. In particular, a method was proposed to detect identifiable rate-measurable wavelength changes depending on the type of nitro-compound. Previously reported nitroaromatic sensors rely on fluorescence quenching technique with a simple reduction in luminescence intensity. Lower sensitivity, lack of selectivity and false positives are perceived as major drawbacks related to the previously known sensors as compared to the fluorescence amplification sensors. Professor In Su Kim said, "This study resulted in the development of a new technology that can selectively detect explosive nitro-compounds, especially fluorescence amplification can be visually identified and this technology can be used to develop small explosive detection sensors, that are easy to carry, in the future." This research was conducted with financial support from the National Research Foundation of Korea and the Ministry of Science and ICT (MSIT). Picture Description < Picture Description > First Figure: When NACs (nitroaromatic explosive compounds) are added to a supramolecular structure comprising a large organic molecule (Bz-TTF-C4P) and a fluorescent rylene dye molecule (PDI, perylenediimide); the giant complex selectively recognize NACs, forming supramolecular assembly and subsequently emitting fluorescence. Second Figure: A schematic representation that suggests, fluorescence can be detected using well-known RH-6G (rhodamine-6G) as the fluorescent chemical compound through similar reaction. < Illustration of cover page for the October issue of JACS > < Term Description > Ratiometric: A method for measuring intensities of emission spectra by utilizing two or more wavelengths to detect changes to local environment. This is usually measured by using special sensors that are sensitive to certain environmental parameters such as; pH, polarity, viscosity, or ion concentration. Fluorescence amplification: It is a technique to measure the amplification of the fluorescence signals released by the fluorescent group by utilizing the fluorescence colorimetric unit. Trinitrotoluene (TNT, 2,4,6-trinitrotoluene): Organic aromatic compound containing three nitro groups, which is used as reference material to compare the strength of bombs and explosives.

  • Research team led by Professor In-Su Kim at School of Pharmacy, Sungkyunkwan University proposes signals for developing

    Pharmacy Prof. KIM, IN SU

    Research team led by Professor In-Su Kim at School of Pharmacy, Sungkyunkwan University proposes signals for developing

    A research team led by Professor In-Su Kim at the School of Pharmacy of Sungkyunkwan University (President: Dong-Ryeol Shin) has developed a synthetic methodology to selectively transform nucleoside analogs, known as the core structure of antiviral drugs. The findings were published in the September issue of the online edition of Angewandte Chemie (IF = 12.959), a world-renowned journal in the field of chemistry. A nucleoside analog is a compound that is designed with an aim to resemble a structural unit of DNA or RNA by modifying the sugar or base which are the basic units of DNA and RNA. Nucleoside analogs because of their inherent characteristics could be absorbed into viral cells and control genomic synthesis and so could be used as an antiviral drug. So far, more than 20 nucleoside analogs have been used to treat various viral infections such as Herpes (HSV), AIDS (HIV), and hepatitis B/C (HBV/HCV). In particular, Remdesivir, which is in the spotlight as new COVID-19 treatment, is also known to contain a nucleoside analog. In this study, Professor In-Su Kim's research team developed the first synthetic method for selective alkylation of a nucleobase in nucleoside analogue by utilizing easily available sulfur ylide. Previously reported alkylation methods of nucleobase require organic solvents and complex processes involving multiple steps with low chemical reactivity, in turn, resulting in additional production costs and limitations for application in the pharmaceutical industry. Sulfur ylide is a reagent developed in 1960 by Nobel Prize-winning professor E. J. Corey, which has been used only in the manufacture of trigonal cyclic compounds. Professor In-Su Kim's research team has created an opportunity to showcase the importance of sulfur ylide as an effective reagent to alkylate nucleoside analogs. In this developed synthetic method water or alcohol is used as a reaction solvent that is considered as environmentally green and also largely reduce the production cost. Professor In-Su Kim said, "The results are new discovery of the reactivity of sulfur ylides for direct functionalization of carbon-hydrogen bonds. In particular, this study has presented a new signal to aid the development of antiviral drugs for human suffering from the new viral infection, and can drastically improve the manufacturing method for nucleoside alkylation compared to the existing multi-stage synthetic process." This research was conducted with financial support from the National Research Foundation of Korea and the Ministry of Science and ICT (MSIT). < Picture Description > Graphic above the green line: A reaction scheme indicating the reaction of nucleoside with sulfur ylide and carbon-hydrogen bond in nucleoside analog to be replaced with an alkyl. Graphic below green: The reaction of Pyrazinones and Azaracils with sulfur ylide in water or alcohol as solvent does not result in the known cyclic trigonal compounds, but rather brings about alkylation of C˗H bond. Reaction mechanism by path a is suggested by Nobel Prize-winner Professor Corey, and reaction mechanism by path b is the result of the current research. External environmental factors such as substrates, reagents, solvent and temperature are very important to control the reaction pathways a and b. The description in front of the four bullet points summarizes the originality and excellence of the current research work. < Term Description > Nucleoside analogues: organic compounds that transforms the phosphoric acid, sugar, and base of DNA and RNA to make it structurally similar to DNA or RNA. Nucleobase: nitrogen-containing biological compounds that form nucleosides, which, in turn, are components of nucleotides, with all of these monomers constituting the basic building blocks of nucleic acids. The five nucleobases of adenine (A), guanine (G), cytosine (C), thymine (T), and uracil (U) are called primary or canonical. Sulfur ylides: organic compounds containing negatively charged atoms (carbon anions) within molecules, and negatively charged carbon elements are directly coupled with heterocarbons (sulfur, phosphorus, or nitrogen) that have positive transmission. Alkylation: organic synthesis that introduces alkyl groups through substitution or addition reactions to organic compounds.

  • Trauma, Disaster Psychological Support, and  The Influence of Coronavirus Disease 19(COVID-19) Pademic on Public's Psych

    Education Prof. LEE, DONGHUN

    Trauma, Disaster Psychological Support, and The Influence of Coronavirus Disease 19(COVID-19) Pademic on Public's Psych

    There is always a danger of potential disaster in our lives. Natural disasters such as earthquakes, typhoons, and tsunami, as well as social disasters increasing as human civilization develops, are threatening our lives. Recently, we even have experienced a virus pandemic that we never imagined before. These disasters can cause material and economic damage such as loss of life, property, and job, as well as social and psychological dysfunction for the disaster victims by remaining as threatening events that shake up one’s life. Since the research team led by Professor Dong Hun Lee of the Department of Education had conducted the R&D of the Ministry of Security and Public Administration from 2014 to 2016, the team has continuously made efforts to study the psychological and social effects of large-scale disasters on people and to establish national-level psychological support measures. [1] ‘OMEGA - Journal of Death and Dying‘(SSCI), August 9, 2020 “A Longitudinal Perspective on Bereaved Parent’s Changes in Life Experience” (Yewon Kim, DongHun Lee, HongJin Jeon) • Individuals who experienced traumatic events may experience extreme psychological pain and fear, with losing their prediction and control of their own lives, especially a feeling of changes in themselves. • According to the study, parents who lost their child to disasters not only experience more powerful and continuous grief and mental health difficulties than other kinds of loss experiences, but also may not recover from the negative effects of grief for a long time. The study suggests that psychological supports for victims of disasters need to be continued to the years beyond the early stages of the incidents. [2] The Influence of Public's Fear, and Psycho-social Experiences during Coronavirus Disease 19(COVID-19) Pandemic on Depression, Anxiety in South Korea, The Korean Journal of Counseling and Psychotherapy 2020, 32(4), In Press, (Lee, DongHun, Kim, YeJin, Lee, DeokHee, Hwang HeeHun, Nam, Seulji, Kim, Ji Yun) • The research team led by Prof. Lee, who published a paper titled <‘The Emotional Distress and Fear of Contagion Related to Middle East Respiratory Syndrome(MERS) on General Public in Korea’ (Dong Hun Lee, Ji-Yun Kim, Hyun-Suk Kang)> (in Korean Journal of Psychology: General in 2016), tried to examine the psychological and social effects of infectious social disasters such as coronavirus on the general public and find out the various causes of new infectious diseases affecting the public's negative psychological experiences. • In this study, infectious diseases such as MERS, SARS, and Influenza A (H1N1) have continuously occurred in South Korea, but it is revealed that "technical disease control" and "emotional guard" should be combined to reduce fear, anxiety and depression of the general public. In addition, since it is impossible to prevent the influx of new infectious diseases and these diseases can occur again at any time, it is important to establish a national-level psychological support plan to cope with future infectious social disasters. ※ Reference - Study on COVID-19 1. Donga https://www.donga.com/news/It/article/all/20200908/102839839/1 2. Yonhapnewstv https://www.yonhapnewstv.co.kr/news/MYH20200906003600038 https://www.yna.co.kr/view/AKR20200905044100004 3. Maeil Business Newspaper https://www.mk.co.kr/news/society/view/2020/09/918328/ - Study on MERS 1. https://news.joins.com/article/23720342 [Original Article: JoongAng Daily] suffering from panic due to stress of coronavirus ... ‘mental prevention’ desperately needed in Daegu 2. http://biz.heraldcorp.com/view.php?ud=20160714000138 The Korea Herald

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