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  • Lung cancer can be quickly diagnosed at low cost

    Chemical Engineering Prof. UM, SOONG HO ·Researcher YUK, JISOO

    Lung cancer can be quickly diagnosed at low cost

    Sungkyunkwan University (President: Dong Ryeol SHIN) announced on July 17 that Prof. Soong Ho UM from the Dept. of Chemical Engineering and Prof. Myung Ju AHN from the Dept. of Hematology and Oncology of SKKU Medical School have identified ways to dramatically improve lung cancer diagnosis. The previous lung cancer screenings took about three weeks with high cost, but as result of this research, it is expected to be diagnosed in vitro within about three hours at low cost. The researchers developed a high-performance nucleic acid nanostructure-graphene oxide complex and realized a high-speed, real-time, and multi-diagnosis of specific gene combinations of lung cancer disease without PCR. The time required for cancer diagnosis was dramatically shortened and applied to liquid biopsy, which is emerging as a non-invasive and patient-friendly cancer diagnosis method. As a result, simultaneous diagnosis of multiple biomarkers of lung cancer applicable to liquid biopsy has opened the possibility of establishing a phased lung cancer treatment model. The first author, Ms. Ji Soo YUK, developed a nucleic acid structure-graphene oxide platform that selectively discriminates the combination of epidermal growth factor receptor (EGFR), a representative biomarker and microRNAs for lung cancer. They are well known as cancer cell fingerprint genes that contain information about the process of cancer cell progress. This platform also enables the distinction of point mutations that show a difference in one single gene mutation. In addition, multiple biomarkers are determined in real time within 3 hours, so that ultra-simplicity and ultra-precision cancer diagnosis can be performed. The mutation of a specific gene or the change in the expression rate of genetic materials is thought to affect the development and progression of cancer. In the case of lung cancer, EGFR gene mutation is a typical biomarker, and 35 ~ 50% of Asian patients are similar. Recently, it has been attracting much attention because it is known that the expression of microRNA (as well as EGFR mutants) directly affects the production of cancer tumor. To detect these genes, target biomaterial samples should be secured by invasive and surgical methods. This causes considerable physical and mental pain for the patient and the utilization of technology is significantly limited depending on the location of the tumor. In addition, the genetic testing process takes weeks after tissue collection. Therefore, a patient-friendly diagnostic method is urgently required to evaluate the suitability and resistance of each patient's drug in a comprehensive manner. In this study, a high-speed diagnostic platform applicable to blood was developed. The mutation of the EGFR gene can be used actively in clinical prescription of the therapeutic agent, and simultaneous identification of the microRNA group will contribute greatly to the discovery and treatment of new cancer biomarkers. The researchers have built a nano-barcoding platform system with a new nano-hybrid material between a fluorescent nucleic acid biopolymer and graphene oxide in a triangular column model. The system is designed to selectively respond to microRNAs originating from lung cancer and specific gene biomarkers such as EGFR mutants, and specific fluorescent switches are designed to react and turn on in the presence of a specific biomarker. This is applicable to various gene biomarkers at the same time and is diagnosed in vitro, so it can be used in various aspects such as gene diagnosis and prevention kit in clinical practice. In fact, we have solved the comprehensive problems of clinical kits and have explored the possibility of precision medicine for the first time. This reagent type platform is commercialized under the name of 'FluorgraTM' in DNANO Inc. (President: Young Ku Lee). “The short-term screening time and the applicability to liquid biopsy are enabling real-time monitoring of drug efficacy in conjunction with fast prescriptions for clinical diagnosis, and thus customized treatment for patients is being realized,” said Professor Soong Ho UM. “This will evolve into a form like a commercialized pregnancy diagnosis kit and provide convenience for health and welfare in daily life as soon as possible.”

  • Ultrafast, ultralow power consuming terabit-scale memory integration based on 2D materials

    Energy Science Prof. YANG, HEEJUN ·Researcher SUN LINFENG

    Ultrafast, ultralow power consuming terabit-scale memory integration based on 2D materials

    Prof. YANG’s research group recently reported a new conceptual memory system that can be integrated up to terabit-scale by using 2D graphene and h-BN. The 2D memory device operates with an ultralow power (micro-Jules) and a time constant of tens of nanoseconds, which is 100 times faster than current non-volatile memory devices (e.g., flash memory). Unlike conventional phase change memory (PRAM) or resistance random access memory (RRAM), such high device integration with 2D materials has demonstrated various fabrication and materials issues. Moreover, most 2D semiconductors have shown not-reliable operations. Prof. YANG’s team conceived a new conceptual memory device: combining volatile and non-volatile memory devices based on representative and most stable 2D materials; graphene and h-BN. Thus, the self-selective memory does not require a ‘selector device’ that is essential for other integrated devices. Moreover, the 2D materials allow device operation with 1000 times lower power consumption and 100 faster speed. Quantum tunneling through the 2D insulator and a reliable filament formation at the inert graphene were used for the operation. Prof. YANG mentioned that the ‘self-selective memory’ is the first case to demonstrate the feasibility for large-scale memory device integration with 2D materials. While conventional oxide materials show the limitations on the operating power and speed, the self-selective memory will be widely used for the future memory applications in AI and other neuromorphic industry. This research has been published in Nature Communications (IF=11.880) on July 18, 2019. Self-selective memory with graphene and h-BN. A memory of ‘SKKU’ with 25 memory cells are demonstrated.

  • Triboelectricity for charging medical implants

    Advanced Materials Science and Engineering Prof. KIM, SANGWOO ·Prof. Hongjoon YOON · Ronan HINCHET

    Triboelectricity for charging medical implants

    Electronic implants offer many benefits but they are all powered by batteries that need to be replaced regularly through surgery, resulting in additional risks and costs. In this regard, powering medical implants is of great interest. Korean researchers at Sungkyunkwan University (SKKU) reported energy harvesting technology driven by ultrasound. Their study will be published through the journal Science on August 2nd. Ultrasound, transmitted through the skin, makes Perfluoroalkoxy (PFA) membrane vibrate with about 200 μm of displacement at 20 kHz. Under ultrasound excitation, the membrane vibrates in a multimode, which ultimately induces continuous triboelectrification. Prof. Sang-Woo Kim's research team suggested the triboelectric energy harvesting technology driven by transcutaneous ultrasound for powering medical implants. His group demonstrated mechanical energy harvesting by ultrasound using a rat skin. They also discovered that harvesting in a porcine tissue is feasible with vibrating and implantable triboelectric generator (VI-TEG). On top of that, they successfully charged Li-ion battery by taking advantage of the triboelectric generators for the first time. Prof. KIM stated that "We showed for the first time the triboelectrification inside the body induced by transcutaneous ultrasound, which enables powering biomedical implants in safe and convenience manner." "We believe that our findings will be influential on future medical implants market." [Reference] R. Hinchet et al., (2019) “Transcutaneous ultrasound energy harvesting using capacitive triboelectric technology.” Science [Main Author] Hong-Joon YOON (Sungkyunkwan University), Sang-Woo KIM (Sungkyunkwan University) * Contact email: Professor Sang-Woo KIM (kimsw1@skku.edu)

  • Syringeable immunotherapeutic nanogel reshapes tumor microenvironment and prevents tumor metastasis and recurrence

    SKKU Advanced Institute of Nano Technology Prof. LIM, YONGTAIK ·SONG, CHANYOUNG

    Syringeable immunotherapeutic nanogel reshapes tumor microenvironment and prevents tumor metastasis and recurrence

    Surgery maintains its strong position as a therapeutic modality for treating established solid tumors, and various immunotherapies, such as cancer vaccines and checkpoint therapies. Adoptive T cell transfer are applied to treat residual tumors after surgery and prevent tumor recurrence and metastasis. However, immunotherapies have a low response rate, which ranges from approximately 5-30% depending on the target tumor. Recently, Prof. Yong Taik LIM’s research team from Sungkyunkwan University reported a syringeable immunomodulatory multidomain nanogel (iGel) that overcame the limitation by reprogramming the pro-tumoral tumor microenvironment (TME) to antitumoral immune niches. Local and extended release of immunomodulatory drugs from iGel deplete immunosuppressive cells, while inducing immunogenic cell death, it increased immunogenicity. When iGel is applied as a local postsurgical treatment, both systemic antitumor immunity and a memory T cell response are generated, and the recurrence and metastasis of tumors to lungs and other organs are significantly inhibited. Reshaping of the TME using iGel also reverts non-responding groups to checkpoint blockade therapies into responding groups. The iGel is expected as an immunotherapeutic platform that can reshape immunosuppressive TMEs and synergize cancer immunotherapy with checkpoint therapies, with minimized systemic toxicity. Thesis Title: Syringeable immunotherapeutic nanogel reshapes tumor microenvironment and prevents tumor metastasis and recurrence

  • Identification of molecular mechanism of dilated cardiomyopathy

    Pharmacy Prof. LEE, JAE CHEOL

    Identification of molecular mechanism of dilated cardiomyopathy

    Professor Jaecheol LEE’s research team (School of Pharmacy) announced that they identified molecular mechanism of dilated cardiomyopathy(DCM) and provided potential drug target using patient-specific induced pluripotent stem cells (iPSCs). Dilated cardiomyopathy (DCM) due to myocardial abnormality is a syndrome accompanied by ventricular dilatation and contraction dysfunction. It has a high prevalence rate of 1 to 2 per 100,000 Korean, but the precise mechanism is unknown. The researchers looked into the cause of the DCM by generating iPSC from family with DCM and differentiating their iPSCs into cardiomyocytes (iPSC-CMs). They observed abnormal nuclear structures in iPSC-CMs with LMNA mutation. On the contrary, nuclear structure is returned to normal when the LMNA mutation was corrected through genome editing technique. They found that abnormal nuclear structure of mutant iPSC-CMs causes the genome-wide epigenetic changes and eventually leads to the activation of platelet-derived growth factor (PDGF) signal pathway that is silenced in normal iPSC-CMs. The results suggest the novel therapeutic targets of DCM by applying some existing drugs approved by US Food and Drug Administration (FDA)in their disease model system. Professor Jaecheol LEE said, "In the era of precision medicine, which can predict diseases through massive genetic information ofpatients, it is necessary to have a technique to experimentally verify such aprediction system” "Our study demonstrates the potential of patient-specific iPSCs system not only for the modeling the specific diseases but also developing new drug for cardiovascular diseases”. This research was supported by Ministry of Science and ICT and National Research Foundation of Korea. It was published online in the world renowned journal “Nature”.

  • First in the world to develop energy storing mechanism of two-dimensional graphene/phosphorene

    Chemical Engineering Prof. PARK, HOSEOK

    First in the world to develop energy storing mechanism of two-dimensional graphene/phosphorene

    Development of Radially Assembled Graphene Microspheres with Sulfur-Nanorods for Lithium-Sulfur Batteries Researchers from Sungkyunkwan University have developed the sulfur nanorods immobilized on radially assembled open-porous graphene microspheres cathode material for Lithium-Sulfur Batteries (LSB). This research was published online on March 12 on ACS Nano. LSB, which have received much attention as a next-generation battery, had some problem to overcome before commercialization, such as low conductivity of sulfur, volume expansion, and shuttle effect. The research team first demonstrated rod-like nanosulfur strongly interacting with hierarchical radiaaly assembled open-porous spherical rGO, which are synthesized through controllable spray-frozen (SF) assembly. In the synthesized composite (rGO/nS), uniformly rod-like sulfur nanoparticles are distrubuted in the areas that formed a strong bond between surface of graphene and sulfur, greatly improving stability of LSB. In addition, the radially open-pore type spherical structure made electrolyte penetration easier, enhancing utilization of sulfur. The synergistic effect of the two have shown excellent stability, and high performance in LSB. As a result, The rGO/nS hybrid provides a specific capacity and first-cycle Coulombic efficiency of 1269.1 mAh/g and 98.5%, respectively. A 4C capacity of 510.3 mAh/g and capacity decay of 0.08% per cycle over 500 cycles. “This synthesis method is a new technology that allows granulation in the ball shape of micro-sized regardless of the type of nanomaterials, while simultaneously controlling the open-porous structure and ball shape.” explained Prof. Ho Seok Park, the corresponding author. Moreover, “it will help to offer a solution that can push ahead with the commercialization of LSB in the future.”, he added. (a) Schematic illustrations about the synthetic procedures of radially oriented open-porous spherical R-rGO/nS and (b) Long-term cycle stability data at 0.1C and Coulombic efficiencies of R-rGO/nS. MXene/Polymer Hybrid Materials for Flexible AC Filtering Electrochemical Capacitors SKKU researchers have successfully realized high volumetric capacitance along with the high-frequency response, and turned the electrochemical capacitor (EC) technology successfully towards the development of form-factor-free miniature and scalable systems for Alternating current (AC) filtering application and energy storage system for pulse energy harvesters. This research was published online on November 8th 2018 in Joule Cell-Press(2019,3,164-176). Aluminum electrolytic capacitors (AECs) have been used as power devices for AC filtering applications, and are critical for the IoT (internet of things) and self-powered wearable sensors. The capacitance of AECs is much lower than that of ECs, called supercapacitor or ultracapacitor. The rigid shape and bulkiness of AECs are obstacles for their use in miniature and flexible systems. Therefore, the development of flexible ECs that provide high volumetric capacitance and operate in the frequency range of AECs would have an enormous impact. This work carried out systematic approaches to tackle different issues of ECs to replace AECs and open up the opportunities for its further development. Particularly to tackle the issue, the porous MXene/conducting polymer hybrid thin films have been produced, which has an interconnected network structure at the optimum composition and thickness. This maximized the charge transport properties and storage capability of the MXene hybrid thin films, areal and volumetric capacitances of 0.56 mF cm-2and24.2Fcm-3 at 120Hz and enabling operation even at a rate of 1,000Vs-1 or from 60 to 10,000Hz, with extreme flexibility and durability. Additionally, Prof. Ho Seok Park claimed that, “the used coating method is scalable and prepared hybrid electrodes are mechanical robust, so readily available recipe to support self-powered wearable electronics through commercialization”. (A) This Figure was selected as the cover image in Joule, (2019), Volume 3, Issue 1, p1-p304. (B) Schematic representation of synthesis approach and digital photographs showing scalability and mechanical features of prepared electrodes. (C) Areal capacitance and (D) AC filtering capability of prepared ECs at different frequencies. (E) Long-term cycle stability of ECs in different mechanical states. Extrinsic Pseudocapacitance of Molecular-Level Controllably Oxidized Black Phosphorus Nanosheets Researchers from Sungkyunkwan University have discovered the new functionalities on the surface of black phosphorus (BP) nanosheets through chemically controlled functionalization at the molecular-level, revealing the new charge storage mechanism, that improves the overall electrochemical performance. The story of this work was published online on December 10 on Nature Materials. Supercapacitor is one of the promising energy storage devices due to its high power density. However, there are clear limitations such as low energy density and poor rate capabilities. Thus, the new storage mechanism of extrinsic pseudocapacitors, storing charges through redox reaction at surface or near surface, is considered to become a candidate of next-generation energy storage devices. This research team has found that P=O sites has an ability for surface redox charge storage. Increasing of P=O sites concentration can provide more capacitance and energy density. However, too much concentration of active P=O sites can drop the electronic conductivity. Therefore, this research work demonstrated the chemical strategy of molecular-level selective ozone driven oxidation to reveal a unique extrinsic pseudocapacitive mechanism of P sites on oxidized BP nanosheets, that are strongly coupled with graphene via strong interlayer bonding. Through this approach, the higher P=O sites concentration can be achieved, while preserving the electronic conductivity as well, resulting in the oxidized BP/graphene hybrid achieves a capacitance of 478 F/g (four times greater than 2D BP) with a rate capability of ~72% (compared to 21.2% for 2D BP) and capacitance retention of ~91% (with high reversibility, 99.6% coulombic efficiency) over 50,000 cycles. “This work demonstrated a truly reversible pseudocapacitance of oxidized P sites for the first time using controlled oxidation and strong interfacial coupling of oxidized BP and graphene, offering the great solution to electrochemical energy storage communities to improve capacitance, rate capabilities as well as cyclic stability.” explained Prof. Ho Seok Park, the corresponding author. (a) Schematic illustration of the molecular-level controlled chemical approach for oxidized BP/graphene hybrid. (b) Electrochemical performance of oxidized BP/graphene hybrid (foBG) compared to oxidized BP/graphene non-hybrid (oBGP), rGO, and 2D BP.

  • Quantum Algorithm for Calculating Molecular Vibronic Spectra

    Chemistry Prof. HUH, JOONSUK

    Quantum Algorithm for Calculating Molecular Vibronic Spectra

    Recently, not only academics but also industries such as Google, IBM, and Intel are interested in quantum computation research. We expect a prototype quantum computer, which can outperform classical computers in 10 years. Among the various applications of quantum computing, quantum computational chemistry would become a major application area of quantum computing. Prof. Huh has been developing quantum simulation method for molecular vibronic spectroscopy for non-universal quantum computers. In this work, an efficient quantum algorithm for the molecular vibronic spectroscopy, which can be operated in the universal quantum computer, was developed. This new quantum algorithm based on the quantum phase estimation algorithm can be applied to more complicated molecular quantum anharmonic oscillator problems. Quantum algorithm for calculating molecular vibronic spectra Classical simulation of quantum algorithm for calculating molecular vibronic spectra

  • Discovering new biological meaning of detecting nucleophilicity

    Medicine Prof. KANG, KYEONG JIN ·Researcher DU EUN JO

    Discovering new biological meaning of detecting nucleophilicity

    Photoreactive chemicals promote photo-injury and aging of the skin by generating radicals and ROS upon sunlight exposure. Vitamin B2, riboflavin, is a well-characterized phototoxin, tightly controlled to be present in the blood at low concentrations through kidney excretion, suggesting that organisms may have evolved to evade the phototoxic effect of essential nutrients. However, the molecular mechanism by which organisms sense phototoxins is unknown. In the submitted manuscript, we identified the sensory mechanism in insects, simultaneously revealing a cryptic property shared by its sensory ligands, phototoxins. Our results indicate that pigment molecules need to be nucleophilic to exert radical-generating (type-I) phototoxicity. To our knowledge, theories or experimental evidence associating nucleophilicity with phototoxicity are unprecedented. Nevertheless, this makes sense in that nucleophilic chemicals are inclined to donate electrons. When photo-excited electrons easily leave pigment molecules due to high nucleophilicity, free radicals can be readily produced from the pigment. We previously showed that nucleophile sensitivity of TRPA1(A) is critical for sensitively sensing free radicals arising from UV illumination (Du et al 2016 eLife). The submitted study together with the previous work indicates that nucleophile sensing ability of TRPA1(A) underlies detection of both cause (phototoxins) and effect (radicals) of phototoxicity as the sensory nexus for photoprotection, establishing nucleophilicity as a fundamental theme of photoreactivity. In addition to the frontier orbital (HOMO-LUMO) energy gap and other photochemical parameters fallibly predicting phototoxins, our study may provide a new strategy to appraise the intrinsic photoreactivity of chemical compounds, which is a concern/interest to researchers developing new drugs for human diseases. While mostly useful to select against type-I phototoxicity, our findings can be implemented to positively identify robust photosensitizers for photodynamic therapy of diseases such as cancer. On the other hand, there have been anecdotes in which oral intake of vitamin Bs repels mosquitoes, while ingestion-based tests discredited them. Our study, examining Anopheles gambiae TRPA1 expressed in frog oocytes, implies that application on clothes rather than ingestion of riboflavin helps avoid mosquito bites that transmit fatal illnesses.

  • CEOs Often Time News Releases to Boost Value of Stock Grants

    SKK GSB Prof. WANG, YANBO

    CEOs Often Time News Releases to Boost Value of Stock Grants

    The timely release of news, from corporate quarterly reports to information about mergers or other significant corporate events, can have major impacts on companies; share prices. Chief executives are well aware of this. As Alex Edmans, Luis Goncalves-Pinto, Yanbo Wang, and Moqi Xu show in Strategic News Releases in Equity Vesting Months (NBER Working Paper No. 20476), CEOs often strategically time the issuance of favorable news releases for the months when their previously agreed upon equity grants are scheduled to vest. This raises the value of their equity positions at the time when they could first liquidate their holdings. For years, public companies have been required by regulators to release certain types of information, such as corporate financials or plans for annual shareholder meetings, on a timely basis as part of the effort to create a level playing field for all investors. Previous studies have shown that both non-discretionary (mandatory) and discretionary (voluntary) news releases by companies can increase liquidity, firm value, and share prices, and they have also explored the roles of CEOs in publicly distributing company information. In this study, the authors sought to determine whether CEOs' participation in the release of discretionary information could be linked to months when their equity grants, often negotiated years in advance, were scheduled to vest. To determine the vesting months for CEOs, the authors relied on data from Equilar between 2006 and 2011 and on hand-collected data from proxy statements and other SEC filings from 1994 to 2005. They found that CEOs were more likely to sell shares during their vesting months, although many CEOs did not sell shares at all. The authors then sampled 160,000 corporate news releases, using a database that allowed them to differentiate between non-discretionary and discretionary releases. They used Thomson Reuters News Analytics to determine whether subsequent media coverage was favorable or non-favorable to the company, and found that, on average, discretionary news releases were associated with positive media coverage. The authors conclude that disclosure of one discretionary news item in a vesting month generated an average 16-day abnormal return of 28 basis points, and that this return was statistically significant. Over 31 days, the return was smaller, suggesting that discretionary news releases may have only temporary price effects. The authors found 5 percent more discretionary news releases in CEO vesting months than in prior months. By linking the timing of discretionary news releases with their data on the exercise of stock options, the authors found that the median interval between a disclosure in a vesting month and the first equity sale by a CEO who sold was five days; the median interval until sale for the CEOs who sold the entire vesting amount was seven days. "This paper shows that managers strategically time the disclosure of discretionary corporate news to coincide with the scheduled vesting of their equity grants," the authors conclude. The news is associated with favorable media coverage and "leads to temporary increases in the stock price and trading volume, consistent with anattention [-getting] story. CEOs exploit these temporary effects."

  • Investigation on the influence of oxygen vacancy location on charge carrier losses in reduced TiO2 nanoparticle

    Chemistry Prof. LEE, JINYONG ·Researcher NAM, YEONSIK

    Investigation on the influence of oxygen vacancy location on charge carrier losses in reduced TiO2 nanoparticle

    A joint research team led by Prof. Jin Yong LEE (Dept. of Chemistry) and Prof. Oleg PREZHDO (Univ. of Southern California in USA) theoretically investigated the influence of oxygen vacancy location on the charge carrier losses in reduced titanium dioxide nanoparticles using quantum calculations. This research was published in the Journal of the Physical Chemistry Letters (IF: 8.709, JCR top 6.76 %) as of 8th May, with the title "Strong Influence of Oxygen Vacancy Location on Charge Carrier Losses in Reduced TiO2 Nanoparticles". Titanium dioxide is definitely the most popular resource for the photocatalytic materials on the fields of academia as well as industry. Currently, the photocatalytic activity of TiO2 is limited by the low absorption efficiency of visible light. Oxygen vacancy defect is artificially introduced or natively exist resulting in the enhancement of the visible light absorption. However, the recent studies reported the contradictory experimental results for photocatalytic activity due to the subsequent change of the electron-hole recombination rate by the oxygen vacancy defect. Still, there are many arguments on the influence of oxygen defect for charge carrier recombination and it has not reached any consensus yet. Prof. LEE’s team theoretically investigated the influence of oxygen vacancy location on the electron-hole recombination rate of reduced titanium dioxide nanoparticle based on quantum calculations for the first time. This work will be very useful to help researchers understand the photocatalytic activities of various experiments handling titanium dioxide nanoparticles. Prof. LEE said, "Our theoretical prediction properly explains the contradictory experimental results for photocatalytic activity of reduced titanium dioxide nanoparticles and our results provide guidelines for rational design of nanoscale metal oxides for solar energy harvesting and utilization." This research was supported by the POSCO Science Fellowship of POSCO TJ Park Foundation, National Research Foundation of Korea (NRF), Korea Institute of Science and Technology Information (KISTI) supercomputing center.

  • Development of chameleon-like semiconductor nano device

    Energy Science Prof. JEONG, MUNSEOK ·Researcher NGOC THANH DUONG

    Development of chameleon-like semiconductor nano device

    Professor Munseok JEONG and researcher Ngoc Thanh Duong (in the doctor’s course) has developed a device technology through a joint research with Prof. Sungjoo LIM. The newly developed device is able to output different notation system (binary, ternary and quinary at maximum) depending on the existence of light. It has been posted on the world renowned journal ACS Nano(IF=13.709)’s April 23rd issue. A normal integrated circuit operates by storing either 1 or 0 as a “bit”. This is because the output of a device is recognized by two types: on and off. If an output larger than ternary notation can be realized in a device, it can extensively improve the performance of integrated circuit. The minimal unit of computer data processing “byte” uses 8 “bit” as the standard unit. Setting 1 byte as a standard, 6561 outputs can be produced by using ternary notation. This is 25 times greater than the binary notation, which produces 256 outputs. Also, if it is possible to realize a quinary notation, the performance will improve 1000 times with just a single byte. [Thesis] inverter device that changes notation by laser reaction The research team used two-dimensional materials such as Molybdenum ditelluride (MoTe2) and Molybdenum disulfide (MoS2) compound to create Van der Waals heterojunction device. They were able to develop multi-level electronic device by using the negative differential transconductance phenomenon discovered from the heterojunction device. Prof. JEONG said, “This research is expected overcome the difficulties in 4th industrial revolution such as the high power consumption of big data and AI and data processing speed by improving the efficiency of electronic devices.” This research was conducted in support of Institute for Basic Science and National Research Foundation of Korea.

  • Elucidating activation mechanism of GPCR-mediated G protein

    Pharmacy Prof. CHUNG, KA YOUNG

    Elucidating activation mechanism of GPCR-mediated G protein

    □ Professor Ka Young CHUNG’s research team (Lead author: Nguyen Minh Duc, Former PhD. student) from School of Pharmacy elucidated the mechanism of G protein activation by GPCR in collaboration with the 2012 Nobel laureate Professor Brian Kobilka’s research team. □ The research has been published in the world renowned journal, “Cell” on May 9th. ※ Journal title : Assmbly of a GPCR-G Protein Complex ※ Main authors : Ka Young Chung (Correspondence, SKKU), Brian K. Kobilka (Correspondence, Stanford University), David Lodowski (Correspondence, Case Western Reserave University), Nguyen Mihn Duc (Lead author, SKKU), Yang Du (Lead author, Stanford University), Soren GF Rasmussen (Lead author, Copenhagen University) □ G protein-coupled receptors (GPCRs) act as the gatekeeper of cell by accepting and transmitting extracellular signals such as hormones and medicines inside the cells. Approximately 40% of marketed drugs target GPCRs, and their importance in normal physiology and pathology was recognized by two scientists (Drs. Kobilka and Lefkowitz), who were awarded with Nobel Prize of Chemistry in 2012. □ The research teams studied the time-resolved structural mechanism of G protein activation by GPCRs. The results suggested that the GPCR-G protein complex structure (2012 Nobel Prize winning topic) occurs as a later event during GPCR-mediated G protein activation, even after GDP release. Therefore, the research group suggested that precise understanding of the early event during GPCR-mediated G protein activation is more appropriate for better understanding of the cellular procedure and development of drugs. □ This research was supported by Ministry of Science and ICT-National Research Foundation of Korea.

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