The research team led by Prof. Do Hyun NAM was selected for the National Research Project by the Ministry of Health and Welfare in 2009 (Institute for Refractory Cancer Research). From that time, the team has been developing the innovative translational research platform, “AVATAR system” which recommends effective therapeutic options for individual patients based on the genomic alterations and drug response profiles (Gene-Drug response Map). To provide the therapeutic recommendation in real time, his research team has streamlined the processes of (1) genomic characterization of patient’s tissue, (2) patient-matched primary cell culture under cancer stem cell culture condition, (3) drug screening using patient derived cell (AVATASCAN®), and (4) drug response validation in the patient derived xenograft model (AVATAR Mouse®). They also developed the (5) software for drug response prediction (AVATAMED) in order to know the sensitivity experienced by the patient from certain chemical treatment. Using the AVATAR system, the team is currently working on genome based patient centered clinical trial for personalized therapy. Through diligent research activities, the research team’s recent major scientific achievements include the analyses of patterns on the genomic mutation depending on the tumor recurrence location (Cancer Cell, 2015) and clonal evolution of glioblastoma under therapy (Nature Genetics, 2016). In addition, research team shows that evolutionary inference from integrated genomic analysis in multisector biopsies can inform targeted therapeutic interventions for patients with brain tumor (Nature Genetics, 2017). By proposing new target therapies for brain tumor patients, his research is receiving great expectation in the hopes of providing treatments that are more precise for brain cancer patient. The team is collaborating with many eminent researchers worldwide to build a global network and try to use such network for establishment of an Initiative for Precision Oncology.