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  • Development of a New Method for Converting MoS2 into MoTe2 by Prof. Young Hee LEE

    Physics Prof. LEE, YOUNGHEE

    Development of a New Method for Converting MoS2 into MoTe2 by Prof. Young Hee LEE

    Prof. Young Hee LEE, Center for Integrated Nanostructure Physics, Institute for Basic Science at Sungkyunkwan University has successfully developed a new method for converting monolayer molybdenum disulfide (MoS2) into molybdenum ditelluride (MoTe2) via substitution of tellurium to MoS2 by chemical vapor deposition (CVD). In order to trigger such a substitutional reaction, High reaction temperature is necessary for Te-substitution but the instability arises because of lower thermal stability of MoTe2 than that of MoS2. Although the MoTe2, which is product after Te-substitution, is vaporized above 700 °C due to the thermal instability, the substitutional reaction below 700 °C is no longer possible. To resolve this issue, we introduced sodium telluride (Na2Te) as a telluriding catalyst and further was able to achieve stable MoTe2 by provoking substitutional reaction at temperature below 700 °C. The research team confirmed that the Te-substitution reaction occurs preferentially from the edge and grain boundary of the MoS2 flake and further constructed lateral hetero semiconductor junction of MoS2-MoTe2. Furthermore, various phases such as alloy (MoS2-xTex), semiconductor (2H-MoTe2), and metal (1T’-MoTe2) were obtained by adjusting experimental parameters of temperature and sodium concentration. We also demonstrated that the band gap of MoS2-xTex alloy can be modulated by controlling the tellurium composition. Dr. Seok Jun YUN, the leading scientist of the research team, predicted that "It is possible to synthesize compound materials by a substitutional technique even for the unstable compounds." The conversion method using the telluriding catalyst (Na2Te) can be applied not only to MoS2 but also to tungsten disulfide (WS2), which is another type of transition metal dichalcogenide. This research, conducted by prof. Young Hee Lee and Seok Joon Yun who is the first author of this research, was published in Nature Communications (IF 12.124), a worldwide scientific journal in science and technology, on December 18.

  • Photosynthetic Production of α-farnesene from CO2 by Profs. Han Min WOO & Hyun Jeong LEE

    Food Science and Biotechnology Prof. WOO, HAN MIN

    Photosynthetic Production of α-farnesene from CO2 by Profs. Han Min WOO & Hyun Jeong LEE

    Solar-to-chemical and solar-to-fuel production from CO2 have been developed using engineered microorganisms that assimilate CO2 and convert target chemicals and fuels using solar energy. In addition to integrated bio-electrochemical systems, photosynthetic cyanobacteria have been metabolically engineered to redirect CO2 to value-added chemicals as bio-solar cell factories. The research team of Profs. Han Min WOO and Hyun Jeong LEE reported the metabolic engineering of unicellular Synechococcus elongatus PCC 7942 to improve the photosynthetic production of α-farnesene from CO2 in the Journal of Agricultural and Food Chemistry, December 6, 2017. As a result of the lack of farnesene synthase (FS) activity in the wild-type cyanobacterium, the research team metabolically engineered S. elongatus PCC 7942 to express heterologous FS from apple fruit, resulting in detectable peaks of α-farnesene. To enhance α-farnesene production, an optimized methylerythritol phosphate (MEP) pathway was introduced in the farnesene-producing strain to supply farnesyl diphosphate. Subsequent cyanobacterial culture with a dodecane overlay resulted in photosynthetic production of α-farnesene from CO2. Prof. WOO said that to the best of our knowledge, this is the first report of photosynthetic production of α-farnesene from CO2 in the unicellular cyanobacterium S. elongatus PCC 7942. This engineered strain could be further optimized to accelerate the development of bio-solar cell factories to convert CO2 to α-farnesene as a value-added bioproduct (fragrance, surfactants, etc.) or α-farnesane, a potential bio-jet fuel. This work was supported by the Korea Carbon Capture & Sequestration R&D Center (KCRC, 2017M1A8A1072034) and the Basic Science Research Program (2017R1A2B2002566 and 2017R1A6A3A01011460) through the National Research Foundation of Korea, funded by the Korean Government [Ministry of Science and Information and Communications Technology (ICT)]. The full article can be accessed at http://pubs.acs.org/doi/full/10.1021/acs.jafc.7b03625.

  • Production of Multilayer Graphene Composite Metals and Alloy Hybrid Nanoparticles

    Advanced Materials Science and Engineering Prof. SUH, SUJEONG

    Production of Multilayer Graphene Composite Metals and Alloy Hybrid Nanoparticles

    Prof. Su Jeong SUH, Director of the Advanced Materials and Process Research Center for IT, deployed infrastructure for research equipment, including a semiconductor process clean room and ultra-precision material analysis equipment, by receiving the designation of Technology Innovation Center (TIC) from the Ministry of Commerce Industry and Energy in 1999. He conducted R&D projects using equipment built with TIC projects after receiving the designation of Regional Research Center (RRC) from the Ministry of Science and Technology in 2002. In addition, he was designated Regional Innovation Center (RIC) by the Ministry of Commerce Industry and Energy in 2006 to expand the industry-university cooperation research infrastructure and also continued to operate diverse education projects and business support projects, including workforce training for semiconducting processes, education in science and engineering for the unemployed, technical exchange meetings, and process technology support. Recently, he was selected as the Smart e-Plating Regional Innovation System (RIS) in 2012, Gyeonggi Regional Research Center (GRRC) by the Ministry of Commerce Industry and Energy, and as the base university of an ernergy cluster project by the Korea Electronic Power Corporation (KEPCO) in 2017. The group is expanding its research into the field of surface treatment processing and advanced sensors and works as a bridghead for intramural academic-industrial sectors. Research Field The Magnetic Material Laboratory of the Department of Advanced Materials Science and Engineering has performed 10 technology transfers and 22 registrations of internal and external patents (7 external) in the past three years. Moreover, recently, Research Professor Young Il SONG has done research as a key person in the laboratory, easily producing eco-friendly multi graphene layer coated single or alloy metal nanoparticles (MGMNs) using a wire electric explosion method. These MGMNs have received widespread attention because of the unique structure of the multi-graphene shells encapsulating second-phase metal cores. The metal particles serve as a protection against environmental degradation effects and oxidation. Furthermore, these novel MGMNs induce unique electronic, optical, and magnetic properties due to quantum confienement and very high surface per volume ratio, which are undoubtedly important for the evolution of nanotechnology. In addition, these MGMNs can be used in various application materials such as energy storage materials, electrode paste, printable ink, catalysts, ferrofluids, and sensors. Our researchers have unfolded not only the development of MGMNs by electric explosion method, but also the development of MGMNs with various metal core nanoparticles by chemical coprecipitation method. This technology also contributes to the increase of battery capacity and the enchancement of power moment output using graphene filme and thse metal nanoparticles on current collectors of lithium ion batteries. We are conducting further research on MGMN-based application devices.

  • Prof. Hyouk Ryeol CHOI Leads the World's Best Professional Service Robot Technology

    Mechanical Engineering Prof. CHOI, HYOUK RYEOL

    Prof. Hyouk Ryeol CHOI Leads the World's Best Professional Service Robot Technology

    Prof. Hyouk Ryeol CHOI (Sungkyunkwan University, School of Mechanical Engineering) established the Intelligent Robotics and Mechatronics System Laboratory (IRMS; it has been changed to Robotics Innovatory, abbreviated RI) in 1995 and has performed research mainly focused on professional service robotics during the last 20 years. For example, smart inpipe inspection robots, ultra long span bridge inspection robots, maintenance robots for sewer and water supply systems, quadruped walking robots for field operations, multi-fingered robot hands and manipulation technology, soft actuators and sensors, and interaction sensing technology for robotics are the subjects of research done by Prof. CHOI with governmental and industrial funding. In addition, Prof. CHOI actively collaborates with researchers from foreign countries such as UNLA, UCLA, UNLV, Qatar University, etc. One of the field robots developed by Prof. CHOI can be MRINSPECT VII. This robot contains most of the core technologies developed by Prof. CHOI on inpipe robot technologies, which can intelligently move inside of urban gas pipelines in service without external support. Its operation has been tested recently in real gas pipelines and proved to be effective in practical applications. MRC^2 IN Series is another field robot dedicated to bridge maintenance service. Among them MRC^2 IN has been built recently for service in cable-supported suspension bridges, which can move over 100mm during the operation. The robot has been tested in Yongjong Grand Bridge in Incheon and validated. Interaction sensing technologies are for sensing physical interactions between robots and the environment such as humans, and thus, force, torque, and proximity caused by the interaction are sensed. Prof. CHOI leads the world's best interaction sensing technologies, especially capacitive type technologies. He has many patents and transferred to the company for commercialization,notably the 6-axis force/torque sensor RFT series. The sensor becomes a strong competitor in the market dominanted by US and Japanese companies. Prof. CHOI has outstanding academic achievements with more than 170 journal papers, books, and 380 proceedings, as well as over 130 domestic and international patents. With these contributions, he received the Grand Robot Prize from the Ministry of Trade and Commerce in 2014, the Academic Career Award from the Korea Robotics Society, the Korea Patent Award, The 10th Achievement Award of Mechanical Engineering in 2016, and the IEEE ICRA Best Human Robot Interaction Paper Award.. He will be the president of the Korea Robotics Society in 2018 (homepage: http://mecha.skku.ac.kr).

  • Identification of Crystal Lattice Structure of 2-dimensional Magnetic Semiconductor

    Mechanical Engineering Prof. LEE, CHANG GU

    Identification of Crystal Lattice Structure of 2-dimensional Magnetic Semiconductor

    A team of Prof. Chang Gu LEE’s group (School of Mechanical Engineering, SKKU) and Prof. Sunmin RYU’s group (Department of Chemistry, Postech) identified the crystal lattice structure of a new 2-dimensional (2D) magnetic semiconductor using optical characterization methods. 2D materials, such as graphene, have atomic thickness and exhibit excellent electrical, mechanical and chemical properties, thus are expected to find abundant applications in next-generation opto/electronic devices. The recently studied binary metal chalcogenides, such as MoS2, consist of 2 elements and show various electrical characteristics and will be used for flexible electronics and displays. However, These materials lack one important physical property, which is magnetism. Since silicon-based electronic circuits are approaching the physical limit in their performances, scientists are searching for alternative electronic devices and materials. Hence, they are paying attention to spintronic devices, which utilize spin along with charge of electrons for device operation. Now, 2D magnetic semiconductors can be a good candidate material for spintronic devices and circuits due to low-dimensionality. The team studied a ternary 2D magnetic semiconductor CrPS4, which consist of chromium, phosphorus, and sulfur to investigate its lattice structure using an optical microscope and Raman spectroscopy and confirmed it with a tunneling electron microscope. It is an antiferromagnetic material and has anisotropic in-plane structure. Therefore, its optical and electrical properties can be dependent on its crystalline orientation. When the polarized light was irradiated on the crystal, the light showed different reflection intensity depending on the crystal direction. And the lattice structure could be identified from angle measurement. This was an important result because the crystal orientation of a material is usually determined by an expensive tool such as tunneling electron microscope. This method can provide a simple but powerful tool for 2D materials researchers to check the crystalline orientation easily and lower the barrier to high-quality experiments. This research will enable many researchers to study these kind materials with ease and can contribute to the studies of spintronics using 2D magnetic semiconductors. This work was published in ACS nano on Nov. 28, 2017. 본 연구는 ‘ACS nano’ 온라인판 10월 25일자에 게재되었으며 광학기술정보통신부와 정보통신기술진흥센터에서 지원하는 사업이다. ETRI와 공동으로 수행하는 ‘차세대 신기능 스마트디바이스 플랫폼을 위한 대면적 이차원소재 및 소자 원천기술 개발’의 일환으로 개발되었다.

  • Development of a pneumococcal vaccine preventing influenza virus as well as pneumococcal infections

    Pharmacy Prof. RHEE, DONG KWON

    Development of a pneumococcal vaccine preventing influenza virus as well as pneumococcal infections

    A team of Prof. Dong-Kwon RHEE (School of Pharmacy, SKKU) and Dr. Man-Ki SONG (International Vaccine Institute; IVI) developed a novel vaccine which can prevent influenza (flu) virus and pneumococcal infections. In this study, PhD student Seung Han SEON and Prof. Sukneung PYO (SKKU), Dr. Jung Ah CHOI and Eunji YANG (IVI) have been participated. The vaccine they developed is highly feasible as a novel vaccine for preventing or mitigating influenza virus as well as pneumococcal infections. To prevent flu infection, it is highly recommended to have flu vaccine every year. Also for pneumococcal diseases prevention, 23 valent polysaccharide vaccine or 13 valent conjugate vaccine is recommended. However, live attenuated vaccine they developed can prevent these irrelevant two infections at the same time. In the year 2009, a new variety of flu virus infection could lead to significant mortality, due to secondary bacterial infection such as pneumococci and Staphylococcus aureus after flu virus infection. Thus, it is essential to develop a vaccine which can prevent secondary bacterial infections after flu pandemic. However, current 13 valent conjugate vaccine could not prevent the pneumococcus infection effectively after flu infection (Metzger et al., 2015). They developed an attenuated pneumococcus vaccine devoid of ‘pep27’ gene and immunized mice intranasally. Subsequently, the immunized mice were challenged with flu virus followed by pneumococcus infections. Immunized group showed significantly higher survival rate than the non-immunized group. Through this study, they also discovered that mice immunized with the live attenuated pneumococcal vaccine showed no body weight decrease after flu virus infection. Since body weight decrease is a token of flu virus infection, this discovery is highly meaningful. Moreover, flu virus titer in the immunized mice lung was much lower than the non-immunized control. This finding can provide a mile stone on vaccine development since vaccine is considered to prevent only a specific pathogen. They are now studying how this intranasal vaccine can provide protection from flu virus as well as pneumococcal infections. Also they are checking whether this vaccine can provide other pathogens infections. This study is supported by Korea Science Foundation and published in advance as a brief report in Journal of Infectious Diseases (Impact Factor 6.273: infectious diseases category top 92.26%) on June 14. Published article: · Seon SH1#, Choi JA2#, Yang E2, Pyo S1, Song MK2*, Rhee DK1*, Intranasal Immunization with an Attenuated Pep27 Mutant Provides Protection from Influenza Virus and Secondary Pneumococcal Infections. J Infect Dis 2017; In Press Abstract: https://academic.oup.com/jid/article-abstract/doi/10.1093/infdis/jix594/4627914 Article (free access): https://academic.oup.com/jid/article/doi/10.1093/infdis/jix594/4627914?guestAccessKey=8a78f6ee-1a14-480a-92e9-5828b113a888 Reference: · Metzger DW, Furuya Y, Salmon SL, Roberts S, Sun K. Limited Efficacy of Antibacterial Vaccination Against Secondary Serotype 3 Pneumococcal Pneumonia Following Influenza Infection. J Infect Dis 2015; 212:445-52.

  • Development of Energy-saving Volume Retarded Osmosis(VRO) - Low Pressure Membrane(LPM) Hybrid System

    Graduate School of Water Resources Prof. JANG, AM

    Development of Energy-saving Volume Retarded Osmosis(VRO) - Low Pressure Membrane(LPM) Hybrid System

    Development of energy-saving volume retarded osmosis (VRO)-low pressure membrane (LPM) hybrid system for water treatment and identification of initial fouling mechanism in forward osmosis water treatment process. Dr. Am JANG, a Professor from the College of Construction and Environmental System Engineering and Graduate School of Water Resources, and his research team have developed volume retarded osmosis (VRO)-low pressure membrane (LPM) hybrid system. The discovery of such novel process has lead to a publication of a paper in "Scientific Report (Impact factor=4.259, upper 16% of JCR journal in multidisciplinary sciences field)", a journal from the publishers of Nature, on November 6th, 2017 (online). Additionally, they have identified the initial organic fouling phenomenon that could occur in spiral-wound forward osmosis process at semi-pilot scale, with the use of real wastewater and the membrane surface analysis method. This lead to a publication in "Chemical engineering journal (primary author: Sung-Ju Im, phD student) (Impact factor = 6.216, upper 4.5% of JCR journals in chemical engineering field)", one of the most powerful and effective journals around the world, on November 2, 2017. Forward Osmosis (FO) technology is a water treatment technology based on the osmotic pressure gradient of both solutions (feed and draw). It has been actively studied in academia and industry, and is considered as a substitute for reverse osmosis-based seawater desalination technology and a next-generation desalination technology. In general, since the forward osmosis technology requires a post-treatment technique for separating the draw solute from a high concentration of the draw solution, many researches and attempts have been made to develop an appropriate post-treatment technique. However, the high operating pressure (energy) of the post-treatment technology is pointed out as a limitation of the forward osmosis technology, and the development of a forward osmosis process that does not require post treatment, or post treatment with low or no energy requirement is urgently needed. Through this research, Professor JANG and his research team, was the first to devise and develope a water treatment system design that can utilize the pressure to be used as the driving force for the low pressure membrane, via increase of draw solution volume in a closed tank. The value of this study is unmeasureably high, seeing as how the limitation of the existing osmosis process was improved, the possibility of practical use of the osmosis process was increased, and the direction of the new osmosis technology was suggested through this study. In addition, the spiral-would forward osmosis element is the most common form of the conventional element types, and it is similar to the reverse osmosis module that is used for seawater desalination. To date, the identification of the fouling phenomena of forward osmosis membranes has been limited to laboratory scale (Lab-scale) or to identifying them using model foulants. However, there are limitations in terms of operating conditions and structural characteristics of elements in order to apply the results to the actual process (element scale or pilot scale). Professor JANG’s research team determined the initial fouling mechanism, when spiral-wound forward osmosis element was used with wastewater as feed solution. The results of this study is very valuable, for it can help comprehensively understand the fouling mechanism of the forward osmosis, allow prediction of overall fouling phenomena in actual process, and help understand overall development of forward osmosis process. Professor Am JANG, who conducted and led the study, said, "The results of this study have a great significance in overcoming the limitation of the forward osmosis process, a next generation water treatment technology. Not only it is significant, but the results from this study is also valuable, since understanding of the fouling phenomena is the key factor in development of forward osmosis technology. " Based on the results of this study, Im Sung-Ju, a phD student and the first author of the published paper, presented at the International Desalination Workshop 2017, and was awarded by the Minister of Land, Transport and Tourism. This study was carried out through researches on forward osmosis-reverse osmosis hybrid system, which is supported by Korea Agency for Infrastructure Technology Advancement, and through monitoring of irreversible foulants in the osmosis - based membrane process, supported by the research project of the Korea Research Foundation. Titles of the published papers: - New concept of pump-less forward osmosis (FO) and low-pressure membrane (LPM) process - Organic fouling characterization of a CTA-based spiral-wound forward osmosis (SWFO) membrane used in wastewater reuse and seawater desalination

  • Investigation for changes of band alignment according to size of titanium dioxide nanoparticles

    Chemistry Prof. LEE, JINYONG

    Investigation for changes of band alignment according to size of titanium dioxide nanoparticles

    A research collaboration team led by Prof. Jin Yong LEE (Dept. of Chemistry) and Prof. Francesc ILLAS (Barcelona Univ. in Spain) theoretically investigated the changes of band alignment according to size of titanium dioxide nanoparticles using quantum calculations. This research was published in the Journal of the Physical Chemistry Letters (IF: 9.353, JCR top 1.4 %) as of 16th November, with the title “Size-Dependent Level Alignment between Rutile and Anatase TiO2 Nanoparticles: Implications for Photocatalysis”. Titanium dioxide is definitely the most popular resource for the photocatalytic materials on the fields of academia as well as industry. They have commonly used a mixture of nanoparticles of anatase and rutile polymorphs to increase photocatalytic activity. Up to now, various experiments have been conducted to demonstrate the type of band alignment between two polymorphs. However, there are many difficulties to guarantee the same experimental condition and uniformity of titanium dioxide samples in each experiment. For this reason, several different types of band alignment have been reported from many experiments. Still many arguments about the type of band alignment have not came to an agreement yet. Prof. Lee group theoretically investigated the changes of band alignment according to the size of titanium dioxide nanoparticles based on quantum calculations for the first time. This work will be very useful to make researchers comprehensively understand the photocatalytic activities of various experiments handling titanium dioxide nanoparticles. Prof. LEE said, “Our theoretical prediction properly explains the type of band alignment for Degussa P25 which is composed of anatase and rutile titanium dioxide nanoparticles and has been commercially and most widely used, and our results on the nanoparticle size effect would provide invaluable information to explain the photocatalytic activity changes between different titanium dioxide samples in real experiments.” This research was supported by the National Research Foundation of Korea (NFR) and Korea Institute of Science and Technology Information (KISTI) supercomputing center.

  • Prof. Doojin RYU Suggests a New Framework of Microstructure Studies and Extends Classical Models

    Economics Prof. RYU, DOOJIN

    Prof. Doojin RYU Suggests a New Framework of Microstructure Studies and Extends Classical Models

    Studies in financial market microstructure examine the intraday price, volume, spread, and volatility dynamics of financial markets and illuminate how the latent demands of market participants are translated into intraday price and trading behaviors. The field of financial market microstructure studies has evolved since the early 90’s. The primitive microstructure models have very simple structures and the earlier microstructure theories do not adequately exploit the rich information provided by the big data of financial markets. Professor Doojin RYU suggests a new framework of microstructure studies and extends classical models in order to reflect various characteristics of intraday transactions and to derive meaningful economic implications. His first microstructure research provides an extended model to answer the question of who has an information edge in a highly fluid options market. It was published in the Journal of Futures Markets, a reputable finance journal, oriented to derivatives markets (“Informed trading in the index option market: The case of KOSPI 200 options,” Journal of Futures Markets, 2008, 28:12, 1118-1146). After the study, he suggests a cross-market microstructure model, which is new in this field. While existing studies only concentrate on the intraday asset price dynamics in a single market, his new approach considers the order and information flows from related asset markets when inferring the intraday dynamics of a main financial market (“Intraday price formation and bid-ask spread components: A new approach using a cross-market model,” Journal of Futures Markets, 2011, 31:12, 1142-1169). Recently, Prof. RYU has suggested comprehensive microstructure models to capture all aspects of microstructure information. The studies are “Considering all microstructure effects: The extension of a trade indicator model, Economics Letters, 2016, 146, 107-110” and “Trade duration, informed trading, and option moneyness, International Review of Economics and Finance, 2016, 44, 395-411”. He also analyzes how the violations of intraday option price monotonicity are related to investor characteristics and other microstructure noises. This study was recently published in the Journal of Futures Markets (“Option market characteristics and price monotonicity violations,” Journal of Futures Markets, 2017, 37:5, 473-498). By analyzing the high-frequency and high-quality information contained in the microstructure dataset of the Korean derivatives markets, he estimates his extended models and suggests important policy and regulatory implications.

  • Prof. Jaesook YUN developed Asymmetric Hydroboration of 1,1-Disubstituted Alkenes by Copper Catalysi

    Chemistry Prof. YUN, JAESOOK

    Prof. Jaesook YUN developed Asymmetric Hydroboration of 1,1-Disubstituted Alkenes by Copper Catalysi

    A research team led by Prof. Jaesook YUN (Dept. of Chemistry) developed the asymmetric hydroboration of 1,1-disubstituted alkenes by copper catalysis. This research was published in the Journal of the American Chemical Society (IF: 13.858) as of 4th October, with the title "Copper-Catalyzed Enantioselective Hydroboration of Unactivated 1,1-Disubstituted Alkenes." This work presents the first highly enantioselective hydroboration of 1,1-dialkylsubstituted alkenes, which has not been solved for last 60 years since the Nobel Laureate H. C. BROWN reported the first asymmetric hydroboration. The method allows facile preparation of enantiomerically-enriched chiral alkyl boron compounds from 1,1-disubstituted alkenes. This work has provided several important clues that could truly be a big step in this research field. Prof. YUN said, "Our strategy will provide a useful synthetic tool for drug or natural product synthesis." This work has been recently selected for the Highlights of Organic Process Research & Development (IF: 2.857) by a group of industrial chemists who evaluated the work as a versatile and practical solution that should find many uses. The highlight will be published in November, 2017. This research was supported by the National Research Foundation of Korea (NRF) and the Basic Research Laboratory (BRL) Program.

  • Development of Next-generation Anticancer Substance beyond Conventional Anticancer Drugs

    Pharmacy Prof. KIM, IN SU

    Development of Next-generation Anticancer Substance beyond Conventional Anticancer Drugs

    Very recently, the research group of Professor In Su KIM, School of Pharmacy at Sungkyunkwan University has published a nice work on the October issue of 'Advanced Synthesis & Catalysis' (IF 6.453, JCR ranking 1.4%, in applied chemistry) and highlighted as a cover picture. Professor In Su KIM’s group has developed a Rh(III)-catalyzed novel synthetic method for 7-azaindole compounds, which known as a key unit structure of drug molecules. In particular, by introducing a selective and efficient amination reaction of carbon-hydrogen bond, they have developed a new effective substance which shows stronger anticancer effect than existing anticancer drugs. Professor In Su KIM is pursuing research to maximize the efficiency of new drug development under the theme of 'Late-Stage Drug Optimization laboratory'. In particular, it has been studying to produce new drug candidates that have anti-cancer, anti-diabetic and antimicrobial effects. The results of the study showed that the unit structure containing an amine group was introduced into an azaindole compounds, found in a variety of pharmaceutical molecules. Synthetic compounds have been shown to have superior anticancer activity than doxorubicin as a well-known anticancer drug. Professor In Su KIM said, "As a new technology that is different from conventional methods, it is a new way to drastically improve the synthesis process of pharmaceuticals, especially anticancer drugs" and “as part of the development of new anticancer drugs, we plan to develop new anticancer drug molecules through our synthetic methodology. " This research was carried out with the support of the Basic Research Support Program (BRL) initiated by the Ministry of Science, ICT and Future Planning (Minister, Young Min YOU) and the National Research Foundation of Korea (President, Moo Je CHO).

  • Prof. Soong Ho UM Discriminates a Tumor Heterogeneity Using a Fluorescence-encoded DNA Nanostructur

    Chemical Engineering Prof. UM, SOONG HO

    Prof. Soong Ho UM Discriminates a Tumor Heterogeneity Using a Fluorescence-encoded DNA Nanostructur

    A tumor is a devastating disease, and it is important to apply appropriate therapeutic and diagnostic tools to accurately detect the cancer stage and type. Early detection of cancer is associated with a higher percentage of recovery after treatment, and it is more important to identify the molecular signature of cancer as early as possible. Micro-RNA, which is abbreviated miR or miRNA, has recently been known as a potential tumor-associated signature that can indicate early cancer development. In addition, because miRNAs regulate transcription of mRNA in the upper level of the cascade, a miRNA network significantly influences cellular metabolism, development, differentiation, establishment, and even stress response. miRNA profiles provide essential clues about metabolic heterology in tumorigenesis. Types and mechanisms of cancer-specific miRNAs can be identified for clinical index. Quantification of multiple miRNAs in a living cell leads to better understanding of cancer. Significant correlation of specific miRNA variances that exist during progression from primary tumor to metastasis can be used to predict the effective diagnosis of whole-stage cancer. Moreover, in addition to a change of tumor concept, in which there is a successive process of clonal evolution at the tumor site, cell-to-cell variation and interfacial communication should be detected for personalized medicine. Several nanotechnology-based systems were developed for miRNA detection at the cellular level. However, quantitative analysis of multiplex miRNAs in a living cell is difficult due to the cellular transport kinetics of each cell type. To date, Prof. Soong Ho UM and Dr. Seung Won SHIN present a novel miRNA detection platform using fluorescence-encoded nanostructured Prof. Soong Ho UM Discriminates a Tumor Heterogeneity Using a Fluorescence-encoded DNA Nanostructur DNA probing for quantitative analysis of multiplexed miRNAs in living cells. His research group has been working for over a decade to design novel molecular diagnostic tool kits based on DNA nanotechnology for biomedical purposes. Nanotechnology-engineered platforms as synthesized can provide highly programmable and predictable labeling of various miRNAs specific to the type of cancer in a technically simple manner at the molecular scale. In this study, Prof. UM and his colleagues demonstrate that it is eventually possible to encode fluorescence colors of cancer-specific miRNA signatures in cells using new DNA nanotechnology and to track the presence of fluorescent cells in in situ. Prof. UM speculates that this novel nanostructured DNA-based diagnosis can provide not only important information for tumorigenesis, but can also be applied in personalized medicine as an easy-to-use tool kit. This demonstration of efficient cancer cell labeling and its in situ cancer-staged tracking and tumor heterogeneity, which may be not easy to be realized without this new scientific tool kit, will be of great interest to anyone who is seeking for a new scientific report for progressive technology developments at a cutting-edge cancer diagnosis. This work was supported by a grant from both the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health & Welfare and the Basic Science Research Programs through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, and Future Planning, Republic of Korea.

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